Results 201 to 210 of about 119,811 (261)

Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency. [PDF]

Epigenetics Chromatin
Venu V, Small EM, Roth C, Adikari SH, Vlot AHC, Sullivan KA, Abeyratne CR, Jacobson D, Starkenburg SR, Sanbonmatsu KY, Steadman CR.   +10 more
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Author Correction: SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape. [PDF]

Nat Commun
Wang Z, Dai R, Kang L, Yang H, Chen Z, He J, Shu L, Zhong Y, Zhang Y, Hua Z, Huang Y, Jiang Y, Li J, Xu L, Lan F, Lin SH, Wong J.   +16 more
europepmc   +1 more source

TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency.

Cell Stem Cell
Kafkia E, Pladevall-Morera D, Argemi-Muntadas L, Wang G, Noberini R, Casòliba-Melich A, Bagés-Arnal S, Anagho-Mattanovich M, Silvério-Alves R, Gassler J, Bonaldi T, Rabelink TJ, Moritz T, Żylicz JJ.   +13 more
europepmc   +1 more source

Butyrate blocks specific histone acetylation by preventing recruitment of p300 to acetylated histones

Jiang M, Psoma A, Lyu J, Chiariello MG, Modderman R, Bianchi F, Incarnato D, Marrink S, Jonkers IH, van den Bogaart G.   +9 more
europepmc   +1 more source

TCA cycle rewiring underpins implantation and histone acetylation programming

Kafkia E, Pladevall-Morera D, Argemi-Muntadas L, Wang G, Noberini R, Bagés-Arnal S, Anagho-Mattanovich M, Silvério-Alves R, Bonaldi T, Rabelink TJ, Moritz T, Żylicz JJ.   +11 more
europepmc   +1 more source

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Histone Acetylation and Histone Deacetylation

Molecular Biotechnology, 2002
Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation--increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II.
Kazuhiro, Ito, Ian M, Adcock
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Patterns of histone acetylation

European Journal of Biochemistry, 1990
The N‐terminal domains of all four core histones are subject to reversible acetylation at certain lysine residues. This modification has been functionally linked to transcription, histone deposition at replication and to histone removal during spermatogenesis.
A W, Thorne, D, Kmiciek, K, Mitchelson, P, Sautiere, C, Crane-Robinson   +4 more
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Histone Acetylation in Neurodevelopment

Current Pharmaceutical Design, 2013
Post-translational modification of histones is a primary mechanism through which epigenetic regulation of DNA transcription does occur. Among these modifications, regulation of histone acetylation state is an important tool to influence gene expression.
Antonio, Contestabile, Silvia, Sintoni
openaire   +2 more sources

Histone acetylation and cancer

Current Opinion in Genetics & Development, 1999
In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved. In the case of colon cancer, induction of the p21 gene by histone
S Y, Archer, R A, Hodin
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Histone acetylation and disease

Cellular and Molecular Life Sciences, 2001
Differential acetylation of histones and transcription factors plays an important regulatory role in developmental processes, proliferation and differentiation. Aberrant acetylation or deacetylation leads to such diverse disorders as leukemia, epithelial cancers, fragile X syndrome and Rubinstein-Taybi syndrome.
S, Timmermann, H, Lehrmann, A, Polesskaya, A, Harel-Bellan   +3 more
openaire   +2 more sources