Results 131 to 140 of about 182,599 (256)

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p

open access: green, 2000
David J. Owen   +8 more
openalex   +2 more sources

In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review

open access: yesEpilepsia, EarlyView.
Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik   +5 more
wiley   +1 more source

Epigenetic control of cell identities from epiblast to gastrulation

open access: yesThe FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

open access: yesThe FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura   +8 more
wiley   +1 more source

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