Results 151 to 160 of about 73,056 (295)

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers. [PDF]

, 2019
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes.
Ando, Mizuo, Bui, Nam Q, Califano, Joseph A, Favorov, Alexander V, Fertig, Elana J, Fisch, Kathleen, Fukusumi, Takahito, Gaykalova, Daria A, Guo, Theresa, Ha, Patrick, Haft, Sunny, Ideker, Trey, Liu, Chao, Mark, Adam, Medetgul-Ernar, Kate, Messer, Karen, Pang, John, Pu, Minya, Ren, Shuling, Saito, Yuki, Sakai, Akihiro, Tamayo, Pablo, Xu, Guorong, Yamasoba, Tatsuya, Yegnasubramanian, Srinivasan   +24 more
core  

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

RrMYB2 Regulates Drought Stress via RrJMJ12‐Dependent Epigenetic Modification in Rosa rugosa

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rosa rugosa (R. rugosa), an economically important crop valued for its fragrance and medicinal properties, is highly susceptible to drought stress under open‐field cultivation. However, the molecular mechanisms underlying its drought response remain largely unexplored.
Mengjuan Bai, Yating Yang, Yunfeng Gao, Mengmeng Xu, Qianxiang Zhang, Shuo Liu, Jun Lu, Jianwen Wang, Changquan Wang, Liguo Feng   +9 more
wiley   +1 more source

Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesis

Nature Communications
Accurate procentriole formation is critical for centriole duplication. However, the holistic transcriptional regulatory mechanisms underlying this process remain elusive. Here, we show that KAT7 crotonylation, facilitated by the crotonyltransferase hMOF,
Meng Wang, Guanqun Mu, Bingquan Qiu, Shuo Wang, Changyu Tao, Yutong Mao, Xinhui Zhao, Jiansong Liu, Keyu Chen, Ziyu Li, Weibin Wang, Ence Yang, Yang Yang   +12 more
doaj   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Nucleosome Recognition by the Piccolo NuA4 Histone Acetyltransferase Complex

, 2007
Christopher Berndsen, William Selleck, Steven J. McBryant, Jeffrey C. Hansen, Song Tan, John M. Denu   +5 more
openalex   +1 more source

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Valproic acid for treatment of traumatic brain injury: Study protocol for the VIBRANT prospective randomized trial

Transfusion, EarlyView.
Abstract Background Traumatic brain injury (TBI) carries significant mortality and morbidity in civilian and military populations. Current treatment guidelines for TBI are primarily supportive, and no pharmacological agent exists to attenuate the progression of brain injury.
Maxime A. Visa, Marjorie R. Liggett, Sharnia Lashley, Umar Bhatti, Zaiba A. Dawood, Alvin Anand, Nathan P. Gill, Denise M. Scholtens, Bowen Wang, Hasan B. Alam   +9 more
wiley   +1 more source

Histone Acetyltransferase and Deacetylase Inhibitors-New Aspects and Developments. [PDF]

Int J Mol Sci, 2023
Ibrahim HS, Sippl W.
europepmc   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source