Results 191 to 200 of about 182,599 (256)

Neutrophil extracellular traps in cancer: From mechanisms to treatments

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
Neutrophil extracellular traps are intricately linked to the tumor microenvironment and play a crucial role in tumorigenesis, metastasis, and related complications. Consequently, NETs‐based tumor biomarkers and therapeutic strategies warrant significant attention.
Yifan Wang, Kangjie Yang, Juan Li, Chuanxin Wang, Peilong Li, Lutao Du   +5 more
wiley   +1 more source

Bioavailability and Bioaccessibility of Grain Polyphenols: A Comprehensive Review

eFood, Volume 6, Issue 3, June 2025.
ABSTRACT Phenolic compounds are highly abundant, heterogeneous substances in plant food sources, especially grains. Wheat contains chlorogenic acid, syringic acid, ferulic acid, and gallic acid, and oats contain polyphenolic compounds such as p‐hydroxybenzoic acid, caffeic acid, syringic acid, vanillic acid, and p‐coumaric acid. Corn also consists of p‐
Fatima Tariq, Fakhar Islam, Bushra Atique, Ahmed Hussien Alawadi, Subbulakshmi Ganesan, Sana Attique, Ashish Singh Chauhan, Ali Imran, Mohd Asif Shah, Hafiz A. R. Suleria   +9 more
wiley   +1 more source

Butyrate Selectively Targets Super‐Enhancers and Transcriptional Networks Associated with Human Mast Cell Function

European Journal of Immunology, Volume 55, Issue 6, June 2025.
Butyrate, a short‐chain fatty acid (SCFA) derived from dietary fibers, selectively inhibits human mast cell activation by targeting transcription start sites (TSS) and super‐enhancers regulating key mast cell genes. Local histone hypoacetylation induced by butyrate likely drives transcriptional suppression and reduced degranulation, providing new ...
Jelle Folkerts, Marjolein J. W. de Bruijn, Wilfred F. J. van IJcken, Rudi W. Hendriks, Ralph Stadhouders   +4 more
wiley   +1 more source

Rare allele of a previously unidentified histone H4 acetyltransferase enhances grain weight, yield, and plant biomass in rice

Proceedings of the National Academy of Sciences of the United States of America, 2014
Xian-Jun Song, Takeshi Kuroha, Madoka Ayano, Tomoyuki Furuta, Keisuke Nagai, Norio Komeda, Shuhei Segami, Kotaro Miura, D. Ogawa, T. Kamura, Takamasa Suzuki, T. Higashiyama, M. Yamasaki, H. Mori, Y. Inukai, Jianzhong Wu, H. Kitano, H. Sakakibara, S. Jacobsen, M. Ashikari   +19 more
semanticscholar   +1 more source

Therapeutic Potential of Polyphenols in Targeting Th17/Treg Balance for Intestinal Barrier Maintenance

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
ABSTRACT The integrity of the intestinal barrier is essential for overall health. Disruption of tight junction (TJs) proteins negatively affects intestinal barrier function, leading to immune imbalances and causing a variety of pathological conditions that are closely associated with the pathogenesis of multiple diseases.
Jiaojiao Fu, Zhenghua Zhao, Da Zhou, Sijing Liu   +3 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Yaf9, a Novel NuA4 Histone Acetyltransferase Subunit, Is Required for the Cellular Response to Spindle Stress in Yeast

, 2003
Ivan Le Masson, David Y. Yu, Kurt Jensen, Anne Chevalier, Régis Courbeyrette, Yves Boulard, M. Mitchell Smith, Carl Mann   +7 more
openalex   +1 more source

Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique

JOR SPINE, Volume 8, Issue 2, June 2025.
The current study improves cyber toxicology as a method of evaluating environmental toxicity and molecular biological qualities in addition to clarifying the possible molecular pathways of nicotine‐induced senescence in IVDD. ABSTRACT Aim Through the use of network toxicology, the research sought to determine whether cellular senescence and associated ...
Chen Jiang, Chao Song, Chaoqi Chen, Baoxin Shen, Lei Yang, Chi Zhang, Fei Liu, Xiaofei Wu, Feng Chen   +8 more
wiley   +1 more source

Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies

MedComm, Volume 6, Issue 6, June 2025.
Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang   +6 more
wiley   +1 more source

A Novel EP300 Variant in an African American Girl With Global Developmental Delay and Leukemia

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
Pathogenic germline missense and in‐frame indel variants in exons 30 or 31 of the EP300 gene are associated with Menke–Hennekam syndrome‐2 (MKHK2). In somatic cells, EP300 variants have been reported in lymphoma, leukemia, and various solid tumors. We present an African American girl with global developmental delay, failure to thrive, microcephaly ...
Subit Barua, Vundavalli V. Murty, Alejandro Iglesias, Jun Liao   +3 more
wiley   +1 more source