Results 191 to 200 of about 73,056 (295)

Pan‐Epigenetic Age Prediction in Mammals

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Across > 1000 human and mouse epigenomes, histone modifications and DNA methylation undergo coordinated, cross‐tissue remodeling at shared genes. ABSTRACT Epigenetic remodeling is a hallmark of aging, yet which epigenetic layers are most affected during aging—and the extent to which they are interrelated—is not well understood.
Zane Koch, Adam Li, Trey Ideker
wiley   +1 more source

NF‐κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor‐Resistant Cutaneous T‐Cell Lymphoma

open access: yesCancer Science, Volume 117, Issue 2, Page 407-417, February 2026.
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Yuto Takahashi   +10 more
wiley   +1 more source

KAT5 histone acetyltransferase mutations in cancer cells. [PDF]

open access: yesMicroPubl Biol, 2022
L Hardison K   +3 more
europepmc   +1 more source

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