Results 61 to 70 of about 182,599 (256)

A New EP300‐Related Syndrome With Prominent Developmental and Immune Phenotypes

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein Taybi syndrome (RTS) is a disorder of chromatin remodeling and transcriptional regulation caused by heterozygous pathogenic variants in CREBBP and EP300. RTS is characterized by a distinct facial gestalt, intellectual disability, structural kidney and heart differences, feeding difficulties, and broad thumbs and great toes ...
Devi Priyanka Maripuri, Jessica Gold, Nina Gold, Alanna Strong   +3 more
wiley   +1 more source

Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.

The Plant Journal, 2015
Exposure to temperatures exceeding the normal optimum levels, or heat stress (HS), constitutes an environmental disruption for plants, resulting in severe growth and development retardation.
Zhaorong Hu, Na Song, Mei Zheng, Xinye Liu, Zhenshan Liu, Jiewen Xing, Junhua Ma, Weiwei Guo, Yingyin Yao, Huiru Peng, Mingming Xin, Daoxiu Zhou, Z. Ni, Qixin Sun   +13 more
semanticscholar   +1 more source

Phenotypic Characterization of Seven Pediatric Patients Diagnosed With KAT6B‐Related Disorders: Case Series and Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genitopatellar syndrome (GPS) and Say‐Barber‐Biesecker‐Young‐Simpson Syndrome (SBBYSS) are clinically distinct neurodevelopmental disorders caused by monoallelic pathogenic variants in KAT6B. In some cases, GPS and SBBYSS features can overlap, determining an intermediate phenotype.
Vittorio Maglione, Antonio Pizzuti, Gioia Mastromoro, Eleonora Cresta, Paola Favata, Maria Cristina Digilio, Rossella Capolino, Maria Lisa Dentici, Lorenzo Sinibaldi, Antonio Novelli, Marco Tartaglia, Gianluca Terrin, Viviana Cardilli   +12 more
wiley   +1 more source

Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function [PDF]

Current Opinion in Structural Biology, 2008
The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form ...
Philip A. Cole, Ronen Marmorstein, Ronen Marmorstein, Yong Tang, Ling Wang   +4 more
openaire   +3 more sources

Noncoding RNAs in Host–Microbiota Interaction

Animal Research and One Health, EarlyView.
The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao, Ni Li, Jingyi Xu, Jianrong Ren, Xiaojun Yang, Xinyi Li, Junhu Yao, Shengru Wu   +7 more
wiley   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

Oncogenesis, 2015
We have previously described novel histone acetyltransferase (HAT) inhibitors that block neuroblastoma cell growth in vitro. Here we show that two selected pyridoisothiazolone HAT inhibitors, PU139 and PU141, induce cellular histone hypoacetylation and ...
Julia M. Gajer, Silviya D. Furdas, A. Gründer, M. Gothwal, Ulrike Heinicke, K. Keller, Frédéric Colland, S. Fulda, Heike L. Pahl, Iduna Fichtner, W. Sippl, Manfred Jung   +11 more
semanticscholar   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

PLoS Pathogens, 2015
Human fungal pathogens like Candida albicans respond to host immune surveillance by rapidly adapting their transcriptional programs. Chromatin assembly factors are involved in the regulation of stress genes by modulating the histone density at these loci.
Michael Tscherner, Florian Zwolanek, S. Jenull, Fritz J. Sedlazeck, A. Petryshyn, Ingrid E. Frohner, J. Mavrianos, N. Chauhan, A. von Haeseler, K. Kuchler   +9 more
semanticscholar   +1 more source