Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins [PDF]
, 2006 BACKGROUND: CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers.
Bergman, Lee M. +5 more
core +2 more sources
Cancer Communications, EarlyView.Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu +12 more
wiley +1 more source
Arginine-Phosphate Salt Bridges Between Histones and DNA: Intermolecular Actuators that Control Nucleosome Architecture [PDF]
, 2014 Structural bioinformatics and van der Waals density functional theory are combined to investigate the mechanochemical impact of a major class of histone-DNA interactions, namely the formation of salt bridges between arginine residues in histones and phosphate groups on the DNA backbone.
arxiv +1 more source
A tailored phospho‐p53 library probes antibody specificity and recognition limitations
ChemBioChem, Accepted Article.The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) play a role in p53 activation, yet their precise mechanisms of action remain elusive due to challenges in ...
Mateusz Hess +6 more
wiley +1 more source
Change Point Analysis of Histone Modifications Reveals Epigenetic Blocks Linking to Physical Domains [PDF]
arXiv, 2013 Histone modification is a vital epigenetic mechanism for transcriptional control in eukaryotes. High-throughput techniques have enabled whole-genome analysis of histone modifications in recent years. However, most studies assume one combination of histone modification invariantly translates to one transcriptional output regardless of local chromatin ...
arxiv
HERVs, transposons and human diseases : part 3 [PDF]
, 2012 Part 1 and 2 of this article can be found through theses links: https://www.um.edu.mt/library/oar//handle/123456789/12961 https://www.um.edu.mt/library/oar//handle/123456789/13012Part 3 of the article.
Baldacchino, Sandra, Grech, Alfred
core +1 more source
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes [PDF]
, 2008 Chromatin modification is important for virtually all aspects of DNA metabolism but little is known about the consequences of such modification in trypanosomatids, early branching protozoa of significant medical and veterinary importance.
Akhtar +83 more
core +2 more sources
Chinese Journal of Lung Cancer, 2013 Lung cancer is one of the most common diseases that endanger health and life of people domestically. A number of recurrence and death of lung cancer originated from metastasis.
Rui CHANG, Jiacong YOU, Qinghua ZHOU
doaj +1 more source
Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes [PDF]
, 2019 Histone variants regulate replication, transcription, DNA damage repair, and chromosome segregation. Though widely accepted as a paradigm, it has not been rigorously demonstrated that histone variants encode unique mechanical properties. Here, we present a new theoretical approach called Minimal Cylinder Analysis (MCA) to determine the Young's modulus ...
arxiv +1 more source
Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening [PDF]
, 2015 Background: The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei.
Bernard A. M. Fang +10 more
core +3 more sources