Results 91 to 100 of about 24,866 (282)

A chemical catalyst enabling histone acylation with endogenous Acyl-CoA

, 2022
Post-translational modifications (PTMs) of proteins, e.g., epigenetic acetylation of lysine residues in histones, are crucial to cellular functions and related to diseases. Chemical tools to directly introducing epigenetic lysine acetylation hold promise
Misuzu, Habazaki, Shigehiro, Kawashima, Motomu, Kanai, Hidetoshi, Kajino, Tomoya, Kujirai, Hitoshi, Kurumizaka, Kenzo, Yamatsugu, Shinsuke, Mizumoto   +7 more
core   +1 more source

A Review of the Effects of Curcumin on Histone Acetyltransferase Activity in the Prevention of Cardiac Hypertrophy

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: Curcumin, a natural polyphenolic compound derived from the rhizome of turmeric, has a cardiovascular protective effects. Histone acetyltransferase (HAT) is a consequential enzyme in processes of cardiac hypertrophy (cardiomegaly)
E Habibi, H Esmaeeli
doaj  

Research progress on the role of histone acetylation regulatory factors during the early embryonic development in animals

浙江大学学报. 农业与生命科学版
Following sperm-egg fusion, animal embryos undergo severe epigenetic reprogramming during the early development, encompassing DNA methylation, histone modification, as well as chromatin remodeling, to ensure that highly differentiated gametes form ...
LI Xiaoteng, ZHAO Panpan, ZHANG Kun
doaj   +1 more source

Polyglutamine Disease: Acetyltransferases Awry

, 2002
Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein ...
Hughes, Robert E., Robert E. Hughes
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Histone deacetylases and their roles in mineralized tissue regeneration

Bone Reports, 2017
Histone acetylation is an important epigenetic mechanism that controls expression of certain genes. It includes non-sequence-based changes of chromosomal regional structure that can alter the expression of genes.
Nam Cong-Nhat Huynh, Vincent Everts, Ruchanee Salingcarnboriboon Ampornaramveth   +2 more
doaj   +1 more source

Additional file 1: Tables S1–S4. of Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

, 2016
Table S1. Characteristics of the study subjects. Table S2. Nomenclature of histone acetyltransferases used in the study. Table S3. Summary of expression levels of KATs analyzed in this study normalized to the expression of GAPDH. Table S4.
Christian Reeps (3526292), Kristina Schwamborn (3526295), Yanshuo Han (3526301), Fadwa Tanios (3526298), Hans-Henning Eckstein (545615), Alma Zernecke (92960), Jian Zhang (1682), Jaroslav Pelisek (140993)   +7 more
core   +1 more source

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, EarlyView.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

Gcn5 histone acetyltransferase is present in the mitoplasts

Biology Open, 2019
ABSTRACTIn Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that GCN5 deletion differently affects the growth of two strains.
Montanari, Arianna, Leo, Manuela, DE LUCA, Veronica, Filetici, Patrizia, Francisci, Silvia   +4 more
openaire   +4 more sources

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source