Results 111 to 120 of about 140,296 (249)

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]

, 2010
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
Ellis Peter, Foad, NS, Christoph M Koch, Saffrey Peter, Dillon, SC, Alexander W Bruce, Dunham Ian, Bruce, A.W., Christoph M. Koch, Shane C. Dillon, Ellis, P, Saffrey, P., Chiang, K., Bye, J., Saffrey, P, James, K, James Keith, Watkins Nicholas A., Dhami, P., Watkins, N.A., Nicholas A. Watkins, Langford, C., Andrews, R.M., Dhami, P, Watkins, NA, Alexander W. Bruce, Bonhoure Nicolas, David Vetrie, Langford, C, Willem H Ouwehand, Chiang Kelly, Langford Cordelia, James, K., Pawandeep Dhami, Dunham, I., Vetrie David, Peter Saffrey, Bye, J, Ouwehand, W.H., Kelly Chiang, Foad Nicola S., Bonhoure, N, Andrews, RM, Willem H. Ouwehand, Shane C Dillon, Nicholas A Watkins, Cordelia Langford, Jackie Bye, Vetrie, D., Koch Christoph M., Bonhoure, N., Nicola S Foad, Koch, CM, Robert M Andrews, Keith James, Peter Ellis, Chiang, K, Ian Dunham, Dillon, S.C., Bruce Alexander W., Andrews Robert M., Dunham, I, Robert M. Andrews, Bye Jackie, Vetrie, D, Foad, N.S., Ellis, P., Bruce, AW, Ouwehand Willem H., Nicolas Bonhoure, Nicola S. Foad, Koch, C.M., Dillon Shane C., Ouwehand, WH, Wutz, A., Dhami Pawandeep   +75 more
core   +2 more sources

Additional file 1: Tables S1–S4. of Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

, 2016
Table S1. Characteristics of the study subjects. Table S2. Nomenclature of histone acetyltransferases used in the study. Table S3. Summary of expression levels of KATs analyzed in this study normalized to the expression of GAPDH. Table S4.
Christian Reeps (3526292), Kristina Schwamborn (3526295), Yanshuo Han (3526301), Fadwa Tanios (3526298), Hans-Henning Eckstein (545615), Alma Zernecke (92960), Jian Zhang (1682), Jaroslav Pelisek (140993)   +7 more
core   +1 more source

Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast [PDF]

, 2010
Histone modifications and the HtrA-like serine protease Nma111p regulate apoptosis in budding yeast David Walter, 2010, PhD Thesis, University of Basel Apoptosis is a form of programmed cell death that plays a central role in development and ...
Walter, David
core   +1 more source

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

, 2011
Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity.
Haisma, Hidde J.; id_orcid, Hidde J. Haisma, Maarsingh, Harm, Ghizzoni, Massimo, Dekker, Frank J.; id_orcid, Haisma, Hidde J., Massimo Ghizzoni, Harm Maarsingh, Dekker, Frank J., Frank J. Dekker   +9 more
core   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Characterization of histone acetyltransferases and deacetylases and their roles in response to dehydration stress in Pyropia yezoensis (Rhodophyta). [PDF]

Front Plant Sci, 2023
Zhang Z, Qian H, Wang Z, Pang Y, Guan X, Poetsch A, Wang D.   +6 more
europepmc   +1 more source

KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source