Modeling the dynamics of bivalent histone modifications [PDF]
arXiv, 2013 Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that
arxiv
Characterization of histone acetyltransferases and deacetylases and their roles in response to dehydration stress in Pyropia yezoensis (Rhodophyta). [PDF]
Front Plant Sci, 2023 Zhang Z +6 more
europepmc +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells
iScienceSummary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj
Opposite responses of nuclear spermidineN8-acetyltransferase and histone acetyltransferase activities to regenerative stimuli in rat liver [PDF]
, 1992 Maria Alfonsina Desiderio
openalex +1 more source
Expression profiles and functional prediction of histone acetyltransferases of the MYST family in kidney renal clear cell carcinoma. [PDF]
BMC Cancer, 2023 Liang F, Li X, Shen X, Yang R, Chen C.
europepmc +1 more source
Assembly of specialised chromatin at Fission Yeast Centromeres [PDF]
, 2015 Despite the conserved essential function of centromeres, centromeric DNA is not conserved between species. There is strong evidence indicating that centromeres are epigenetically regulated. Although centromeres normally assemble on preferred sequences,
Pidoux, Alison L.
core
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, EarlyView.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, EarlyView.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. [PDF]
Eur J Med Chem, 2022 Nie S +6 more
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