Results 171 to 180 of about 140,296 (249)

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

The important role of the histone acetyltransferases p300/CBP in cancer and the promising anticancer effects of p300/CBP inhibitors. [PDF]

Cell Biol Toxicol
Wu X, Zhang X, Tang S, Wang Y.
europepmc   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Molecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress. [PDF]

Parasit Vectors
Pei T, Zhang M, Gao Z, Li L, Bing Z, Meng J, Nwanade CF, Yuan C, Yu Z, Liu J.   +9 more
europepmc   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

Dysfunction of duplicated pair rice histone acetyltransferases causes segregation distortion and an interspecific reproductive barrier. [PDF]

Nat Commun
Liao B, Xiang YH, Li Y, Yang KY, Shan JX, Ye WW, Dong NQ, Kan Y, Yang YB, Zhao HY, Yu HX, Lu ZQ, Zhao Y, Zhao Q, Guo D, Guo SQ, Lei JJ, Mu XR, Cao YJ, Han B, Lin HX.   +20 more
europepmc   +1 more source

Elucidating the Role of SET as a Key Contributor to Neurodevelopmental Disability Within the 9q34.11 Deletion Syndrome Interval

Clinical Genetics, Volume 110, Issue 4, Page 438-448, October 2026.
This study reports a female proband with a de novo 9q34.11 deletion affecting SET, who underwent a 28‐year diagnostic odyssey after an atypical Rett syndrome clinical diagnosis. Genomic and proteomics analyses confirmed SET haploinsufficiency, refining the critical 9q34.11 region, and supporting speech therapy benefits in improving meaningful ...
Angelo Condell, Elaine Zhang, Tim Sikora, Sean Massey, Nicole J. Van Bergen, Min Wang, Cas Simons, Katrina M. Bell, Daniella H. Hock, David A. Stroud, David Francis, Wendy A. Gold, Martin B. Delatycki, John Christodoulou, Simranpreet Kaur   +14 more
wiley   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. [PDF]

J Biol Chem, 2018
Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T.   +14 more
europepmc   +1 more source