Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach +4 more
wiley +2 more sources
Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin. [PDF]
Int J Mol Sci, 2019 Shin EJ +5 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Epigenetic Alterations Induced by Photothrombotic Stroke in the Rat Cerebral Cortex: Deacetylation of Histone h3, Upregulation of Histone Deacetylases and Histone Acetyltransferases. [PDF]
Int J Mol Sci, 2019 Demyanenko S, Uzdensky A.
europepmc +1 more source
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, Volume 13, Issue 33, 15 June 2026.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, Volume 13, Issue 35, 24 June 2026.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
Diversity, evolution and expression profiles of histone acetyltransferases and deacetylases in oomycetes. [PDF]
BMC Genomics, 2016 Wang XW, Guo LY, Han M, Shan K.
europepmc +1 more source