Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening. [PDF]
Methods Enzymol, 2016 McCullough CE, Marmorstein R.
europepmc +1 more source
T Cell Exhaustion as a Regulated Differentiation Programme
European Journal of Immunology, Volume 56, Issue 6, June 2026.This review highlights T cell exhaustion as an adaptive differentiation trajectory, not dysfunction, showing how precursor, intermediate, and terminal exhausted states maintain antigen recognition while limiting tissue damage in chronic immune activation.
Marc Veldhoen, Cristina Ferreira
wiley +1 more source
Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases. [PDF]
Cancer Immunol Res, 2017 Hu J +7 more
europepmc +1 more source
Compact Cas12 Systems for Multiplex Engineering of Plant Abiotic‐Stress Networks
Advanced Genetics, Volume 7, Issue 2, June 2026.ABSTRACT Compact CRISPR‐Cas12 platforms, particularly miniature and hypercompact effectors such as Cas12f, Cas12j/CasPhi, and Cas12lambda, are emerging as delivery‐efficient tools for plant genome engineering because their reduced coding size facilitates viral‐replicon and other size‐constrained delivery routes while supporting dense guide multiplexing.
Samar G. Thabet +5 more
wiley +1 more source
Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus
MicrobiologyOpen, Volume 15, Issue 3, June 2026.▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque +4 more
wiley +1 more source
Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors. [PDF]
Chem Biol, 2015 Montgomery DC +4 more
europepmc +1 more source
Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application
MedComm, Volume 7, Issue 6, June 2026.The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang +12 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr +37 more
wiley +1 more source
Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm. [PDF]
Clin Epigenetics, 2016 Han Y +7 more
europepmc +1 more source