Results 211 to 220 of about 241,476 (303)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

open access: yesAdvanced Science, Volume 13, Issue 37, 3 July 2026.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi   +7 more
wiley   +1 more source

Gastrointestinal Manifestations in Rubinstein‐Taybi Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1491-1497, July 2026.
ABSTRACT Rubinstein–Taybi syndrome is a rare genetic condition associated with a wide range of physical, cognitive, and developmental impairments, yet its gastrointestinal manifestations remain poorly characterized. Case reports and small series suggest a high prevalence of gastroesophageal reflux, constipation, dysphagia, and nutritional compromise ...
Mohamad Abi Nassif   +3 more
wiley   +1 more source

Sodium Butyrate Attenuates Sevoflurane‐Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Repeated exposure to sevoflurane in neonatal mice leads to impaired myelin development and neurobehavioral dysfunction, a process closely associated with reduced butyrate levels in vivo. Sodium butyrate supplementation effectively ameliorates these sevoflurane‐induced abnormalities by downregulating HDAC3 and HDAC8 expression, enhancing H3K9ac levels ...
Chang Liu   +6 more
wiley   +1 more source

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. [PDF]

open access: yesACS Med Chem Lett, 2018
Michaelides MR   +20 more
europepmc   +1 more source

Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 7, July 2026.
ERO1A exhibits oncogenic functions, including promoting tumour progression, metastasis, epithelial‒mesenchymal transition, angiogenesis, immune evasion and metabolic reprogramming. ERO1A is also identified as a diagnostic biomarker and a factor contributing to therapy resistance (chemotherapy and immunotherapy).
Jing Mao, Kai Wang
wiley   +1 more source

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

open access: yesMolecules and Cells, 2001
N. Barlev   +6 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy