Results 221 to 230 of about 241,476 (303)
Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.A transcriptome‐based succinylation score (SS) stratifies prostate cancer by prognosis, immune contexture, and chemotherapy sensitivity. KAT2A is enriched in low‐SS, chemoresistant tumours and promotes resistance by succinylating PIK3R2. KAT2A‐mediated succinylation competitively inhibits PIK3R2 ubiquitination, stabilising PIK3R2 and driving ...
Antao Dong +6 more
wiley +1 more source
Role of LncSNHG5 in MAFLD: Mechanisms of Arid1a K391 lactylation and lipid accumulation
Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.1. SNHG5 is significantly upregulated in MAFLD. 2. SNHG5 promotes hepatic lipid accumulation by downregulating MCT1 and regulating intracellular lactate metabolism. 3. SNHG5 drives lactylation of Arid1a at the K391 residue through the P300 and HBO1 acyltransferases. Abstract Introduction Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a
Xinmiao Li +5 more
wiley +1 more source
Multiple myeloma: A tale of deregulated transcription factors
HemaSphere, Volume 10, Issue 7, July 2026.Abstract A comprehensive understanding of the molecular mechanisms underlying multiple myeloma (MM) pathogenesis is essential for developing therapeutic strategies that overcome disease heterogeneity and treatment relapse. In this review, we focus on transcription factors (TFs), key regulators of gene expression that play critical roles in normal ...
Nahia Gómez‐Echarte +5 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 7, July 2026.ABSTRACT Background and Aims Filippi syndrome is a very rare autosomal recessive craniodigital disorder primarily caused by mutations in the gene CKAP2L, characterized by syndactyly, microcephaly, growth retardation, distinctive craniofacial features, and intellectual disability.
Muhammad Anas Faheem +9 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho +7 more
wiley +1 more source
In Vitro Activity Assays for MYST Histone Acetyltransferases and Adaptation for High-Throughput Inhibitor Screening. [PDF]
Methods Enzymol, 2016 McCullough CE, Marmorstein R.
europepmc +1 more source
MYST-family histone acetyltransferases: beyond chromatin
Cellular and Molecular Life Sciences, 2011 Vasileia Sapountzi, J. Côté
semanticscholar +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
MedComm, Volume 7, Issue 7, July 2026.Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source
Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases. [PDF]
Cancer Immunol Res, 2017 Hu J +7 more
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MedComm, Volume 7, Issue 7, July 2026.This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley +1 more source