Traditional Chinese Medicine Intervention Based on Metabolic-Epigenetic Axis: Mechanism and Treatment Strategy of Chronic Heart Failure. [PDF]
He JC +5 more
europepmc +1 more source
Chromatin dynamics and cellular energy homeostasis. [PDF]
Suganuma T, Workman JL.
europepmc +1 more source
Integrative pan-cancer and COAD-focused multi-omics analysis of non-histone acetylation substrate-related transcriptional landscapes. [PDF]
Zhu J +9 more
europepmc +1 more source
Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease
Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription ...
Angela Koehler, André Richters
exaly +2 more sources
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases [PDF]
p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the
Vasily Ogryzko +2 more
exaly +2 more sources
Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)
A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of ...
Rosaria Benedetti +2 more
exaly +2 more sources
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