Results 231 to 240 of about 140,296 (249)

Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in Disease

open access: yesCurrent Medicinal Chemistry, 2017
Histone acetyltransferases (HATs) are epigenetic drivers that catalyze the acetyl transfer from acetyl-CoA to lysines of both histone and non-histone substrates and thereby induce transcription either by chromatin remodeling or direct transcription ...
Angela Koehler, André Richters
exaly   +2 more sources

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases [PDF]

open access: yesCell, 1996
p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the
Vasily Ogryzko   +2 more
exaly   +2 more sources

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs)

open access: yesBioorganic and Medicinal Chemistry, 2011
A novel class of KAT modulators (long chain alkylidenemalonates, LoCAMs) has been identified. Variations of the alkyl chain length can change the activity profile from inhibition of both KAT3A/KAT2B (as derivative 2a) to the peculiar profile of ...
Rosaria Benedetti   +2 more
exaly   +2 more sources

Role of histone acetyltransferases MOF and Tip60 in genome stability

DNA Repair, 2021
Mohammad Altaf   +2 more
exaly  

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