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Histone chaperones and nucleosome assembly
Current Opinion in Structural Biology, 2003Recent structures of the nucleosome core particle reveal details of histone-histone and histone-DNA interactions. These structures have now set the stage for understanding chromatin assembly and dynamics during replication and transcription. Histone chaperones and chromatin remodeling complexes are important in both of these processes.
Christopher W, Akey, Karolin, Luger
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Histone Chaperones: Assisting Histone Traffic and Nucleosome Dynamics
Annual Review of Biochemistry, 2014The functional organization of eukaryotic DNA into chromatin uses histones as components of its building block, the nucleosome. Histone chaperones, which are proteins that escort histones throughout their cellular life, are key actors in all facets of histone metabolism; they regulate the supply and dynamics of histones at chromatin for its assembly ...
Zachary A. Gurard-Levin +2 more
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Histone chaperones: an escort network regulating histone traffic
Nature Structural & Molecular Biology, 2007In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be accessed for processes such as transcription and repair. Histones, the chief protein component of chromatin, must be assembled, replaced or exchanged to preserve or change this organization according to cellular needs.
Leanne, De Koning +3 more
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Histone chaperones, a supporting role in the limelight
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2004In eukaryotic cells, highly basic histone proteins are associated with the DNA to form the nucleosome, the fundamental unit of chromatin. Histones are closely escorted by histone chaperones from their point of synthesis up to their delivery site. We will present an overview of the histone chaperones identified to date with their various roles, in an ...
Alejandra, Loyola, Genevieve, Almouzni
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Structure and function of histone chaperone FACT
Molecular Biology, 2015FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the preservation and recovery of the nucleosome structure during and after transcription, replication and repair of DNA ...
M T, Bondarenko +6 more
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Functions Of The Histone Chaperone Nucleolin In Diseases
2007Alteration of nuclear morphology is often used by pathologist as diagnostic marker for malignancies like cancer. In particular, the staining of cells by the silver staining methods (AgNOR) has been proved to be an important tool for predicting the clinical outcome of some cancer diseases.
Storck, Sébastien +3 more
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Developmental roles of histone H3 variants and their chaperones
Trends in Genetics, 2013Animal development and lifetime potential exploit a balance between the stability and plasticity of cellular identity. Within the nucleus, this is controlled by an interplay involving lineage-specific transcription factors and chromatin dynamics. Histone H3 variants contribute to chromatin dynamics through the timing and sites of their incorporation ...
Dan Filipescu +2 more
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Histone Chaperones, Epigenetics, and Cancer
2013Histone chaperones such as CAF1, ASF1, HIRA, DEK, DAXX, and several others play central roles in the transport, modification, replication, and replacement of nucleosomes. These diverse roles affect many processes including epigenetic memory, genome stability, transcription, Polycomb function, and others.
Mina Rafiei, Rod Bremner
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Histone Chaperones in Chromatin Dynamics
2007Histone chaperones are the histone interacting factors that stimulate histone transfer reaction without being a part of the final product. They are involved in the histone storage, histone translocation to the nucleus, and histone exchange and histone deposition onto the DNA for replication dependent chromatin assembly.
Jayasha, Shandilya +3 more
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