Results 221 to 230 of about 31,898 (266)

Internalized Evolutionary Inertia on Body Plan Evolution

Evolution &Development, Volume 28, Issue 2, June 2026.
Animal development appears to intrinsically bias phenotypic evolution, though the exact mechanism is unclear. This review discusses potential mechanisms by which animal embryogenesis limits phenotypic diversification and considers whether inherent evolutionary inertia could allow us to predict future evolutionary paths.
Wenxin Zeng, Naoki Irie
wiley   +1 more source

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain

The disassembly and reassembly of nucleosomes by histone chaperones is an essential activity during eukaryotic transcription elongation. This highly conserved process maintains chromatin integrity by transiently removing nucleosomes as barriers and then ...
Warner, James Lawrence
core  

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency. [PDF]

iScience
Lorton BM, Warren C, Ilyas H, Nandigrami P, Hegde S, Cahill S, Lehman SM, Shabanowitz J, Hunt DF, Fiser A, Cowburn D, Shechter D.   +11 more
europepmc   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3656-3678, June 2026.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source

The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repair. [PDF]

Plant Cell
Fan T, Shi T, Sui R, Wang J, Kang H, Yu Y, Zhu Y.   +6 more
europepmc   +1 more source

An unexpected histone chaperone function for the MIER1 histone deacetylase complex

, 2022
Wang S, Fairall L, Pham K, Ragan TJ, Vashi D, Collins MO, Dominguez C, Schwabe JW.   +7 more
europepmc   +1 more source

Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma. [PDF]

Sci Rep
Liu Y, Liu S, Jing R, Li C, Guo Y, Cai Z, Xi P, Dai P, Jia L, Zhu H, Zhang X.   +10 more
europepmc   +1 more source

Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism. [PDF]

Cell Stress Chaperones
Shrestha B, Nieminen AI, Matilainen O.
europepmc   +1 more source