Results 161 to 170 of about 102,004 (245)

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases. [PDF]

Cell Prolif
Zhang LY, Wang YY, Wen R, Zhang TN, Yang N.   +4 more
europepmc   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates. [PDF]

Pharmaceuticals (Basel)
Lima ADS, Lima LM.
europepmc   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Design, synthesis and antiproliferative activity of oxadiazole derivatives as potent glycogen synthase kinase-3/histone deacetylase 6 dual inhibitors. [PDF]

J Enzyme Inhib Med Chem
Ye C, Chen Z, Jiang J, Li J, Kong R, Liu S, Chen X, Xu Z.   +7 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. [PDF]

J Cell Sci
Abrol R, Afroz SF, Curson JEB, Raven KD, Das Gupta K, Gunther KS, Jones A, Reid RC, Xiong Z, Gunter JH, Engel JA, Engwerda CR, Blumenthal A, Fairlie DP, Parton RG, Zuryn S, Kapetanovic R, Ramnath D, Sweet MJ.   +18 more
europepmc   +1 more source

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, EarlyView.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review). [PDF]

Int J Mol Med
Ma X, Wei R, Song A, Zhang X, Zou J, Hao S.   +5 more
europepmc   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source