Results 21 to 30 of about 183,209 (216)
Histone Deacetylases in Stroke
Chinese Journal of Physiology, 2019 Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability
Mei-Han Kao, Teng-Nan Lin
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Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex
Nature Communications, 2023 Lysine acetylation in histone tails is a key post-translational modification that controls transcription activation. Histone deacetylase complexes remove histone acetylation, thereby repressing transcription and regulating the transcriptional output of ...
Mandy S. M. Wan +5 more
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Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]
, 2017 Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello +3 more
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Nature Communications, 2020 In S. pombe, small non-coding RNA mediates heterochromatin formation by recruiting the nucleosome remodeling and histone deacetylase complex. Here, the authors show that fly nucleosome remodeler Mi-2 and histone deacetylase Rpd3 are involved in piRNA ...
Bruno Mugat +9 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without ...
Zachary Pickell +3 more
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Potential of histone deacetylase inhibitors for the therapy of ovarian cancer
Frontiers in Oncology, 2022 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemotherapy increase patient mortality.
Fengyi Guo, Hongjing Wang, Hongjing Wang
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Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke [PDF]
, 2008 Cigarette smoke (CS)–induced lung inflammation involves the reduction of histone deacetylase 2 (HDAC2) abundance, which is associated with steroid resistance in patients with chronic obstructive pulmonary disease and in individuals with severe asthma who
Adenuga, David +4 more
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Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy. [PDF]
PLoS ONE, 2014 Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations.
Michael Bordonaro +3 more
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Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
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Haematologica, 2010 Background During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are ...
Peng Ji +4 more
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