Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors [PDF]
Pharmaceuticals, 2022 Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal.
Rupesh Agarwal +5 more
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Roles of Histone Deacetylase 4 in the Inflammatory and Metabolic Processes [PDF]
Diabetes & Metabolism JournalHistone deacetylase 4 (HDAC4), a class IIa HDAC, has gained attention as a potential therapeutic target in treating inflammatory and metabolic processes based on its essential role in various biological pathways by deacetylating non-histone proteins ...
Hyunju Kang +3 more
doaj +4 more sources
Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4. [PDF]
PLoS ONE, 2016 Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought
Yu Tina Zhao +5 more
doaj +5 more sources
HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors [PDF]
Frontiers in Physiology, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
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Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells [PDF]
Brain Sciences, 2023 (1) Background: Parkinson’s disease (PD) is the most common movement disorder. Imbalanced protein homeostasis and α-syn aggregation are involved in PD pathogenesis.
Luxi Wang +10 more
doaj +2 more sources
Mechanistic Insights into Binding of Ligands with Thiazolidinedione Warhead to Human Histone Deacetylase 4 [PDF]
Pharmaceuticals, 2021 Recently, we have reported that non-hydroxamate thiazolidinedione (TZD) analogs are capable of inhibiting human deacetylase 4 (HDAC4). This study aims at the dissection of the molecular determinants and kinetics of the molecular recognition of TZD ...
Markus Schweipert +9 more
doaj +2 more sources
Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma [PDF]
Journal of Translational Medicine, 2022 Background Histone deacetylases (HDACs) have been identified to be implicated in the carcinogenesis and cancer progression. The present study was performed to probe into the effect of HDAC4 on radioresistance of esophageal carcinoma (EC).
Zhonghua Lu +4 more
doaj +2 more sources
Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation [PDF]
Frontiers in Physiology, 2021 Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac ...
Yinlong Zhao +13 more
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Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1 [PDF]
Cell Adhesion & Migration, 2019 In this study, we investigated the role ofhistone deacetylase 4 (HDAC4) and MEG3/miR-125a-5p/interferonregulatoryfactor 1 (IRF1) on vascular smooth muscle cell (VSMCs)proliferation.
Xiangtao Zheng +6 more
doaj +2 more sources
4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells
Applied Sciences, 2021 Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance.
Jwa-Young Kim +4 more
doaj +1 more source