Results 11 to 20 of about 155,197 (274)

Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke

Neurobiology of Disease, 2016
Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is highly
Hui Yuan, Kyle Denton, Lin Liu, Xue-Jun Li, Sharon Benashski, Louise McCullough, Jun Li   +6 more
doaj   +3 more sources

Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans [PDF]

npj Microgravity, 2021
Epigenetic changes during long-term spaceflight are beginning to be studied by NASA’s twin astronauts and other model organisms. Here, we evaluate the epigenetic regulation of gene expression in space-flown C.
Atsushi Higashitani, Toko Hashizume, Mai Takiura, Nahoko Higashitani, Mika Teranishi, Rika Oshima, Sachiko Yano, Kana Kuriyama, Akira Higashibata   +8 more
doaj   +3 more sources

Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts. [PDF]

Aging (Albany NY), 2022
Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging. Previously, we demonstrated that HDAC4 is consistently downregulated in aged and ultraviolet (UV)-irradiated human skin in vivo.
Lee Y, Song MJ, Park JH, Shin MH, Kim MK, Hwang D, Lee DH, Chung JH.   +7 more
europepmc   +4 more sources

Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation. [PDF]

J Mol Cell Biol, 2020
Abstract Protein modification by small ubiquitin-like modifier (SUMO) is an important regulatory mechanism for multiple cellular processes. Although the canonical pathway involving the ubiquitylation or phosphorylation of IκBα has been well characterized, little is known about the sumoylation of IκBα in the control of NF-κB activity ...
Yang Q, Tang J, Xu C, Zhao H, Zhou Y, Wang Y, Yang M, Chen X, Chen J.   +8 more
europepmc   +4 more sources

Resveratrol affects hepatic gluconeogenesis via histone deacetylase 4. [PDF]

Diabetes Metab Syndr Obes, 2019
The aim of this study was to determine whether resveratrol (Rev) affects the expression, phosphorylation, and nuclear and cytoplasmic distribution of histone deacetylase 4 (HDAC4), which in turn affects gluconeogenesis in hepatocytes under an insulin-resistant state.HepG2 cells were treated with 0.25 mmol/L palmitic acid (PA) to establish an insulin ...
Zhao H, Shu L, Huang W, Song G, Ma H.
europepmc   +4 more sources

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]

, 2007
In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba, Antony M. Carr, BG Mellone, C Martin, Carolina Bonilla, D Robyr, David Lando, E Metzger, E Nicolas, Ernest D. Laue, G Rigaut, GW Humphrey, I Sinha, IM Hall, J Bahler, J Nakayama, James Cauwood, JF Flanagan, JJ Tasto, Juan Valcarcel, Julian Walfridsson, K Noma, K Yamane, Karl Ekwall, M Wiren, MA Hakimi, MG Lee, MG Lee, Michael Opel, MJ Buck, Natalia V. Murzina, P Bjerling, PA Cloos, Petra J.H. Werler, PJ Werler, R Schneider, RJ Klose, RJ Sims 3rd, Robin C. Allshire, Sarah C. Trewick, SI Grewal, SK Kurdistani, Tony Kouzarides, U Kleeberg, Y Shi, Y Shi, Y Tsukada, Y Xue, YJ Shi   +48 more
core   +10 more sources

Stroke Induces Nuclear Shuttling of Histone Deacetylase 4. [PDF]

Stroke, 2015
Background and Purpose— Histone deacetylases (HDACs) 4 and 5 are abundantly expressed in the brain and have been implicated in the regulation of neurodegeneration. Under physiological conditions, HDACs 4 and 5 are expressed in the cytoplasm of brain cells where they cannot directly access chromatin.
Kassis H, Shehadah A, Chopp M, Roberts C, Zhang ZG.   +4 more
europepmc   +4 more sources

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis [PDF]

Cell, 2004
Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Vega, Rick B., Matsuda, Koichi, Oh, Junyoung, Barbosa, Ana C., Yang, Xiangli, Meadows, Eric, McAnally, John, Pomajzl, Chris, Shelton, John M., Richardson, James A., Karsenty, Gerard, Olson, Eric N.   +11 more
openaire   +2 more sources

Induction of DARPP-32 by brain-derived neurotrophic factor in striatal neurons in vitro is modified by histone deacetylase inhibitors and Nab2. [PDF]

PLoS ONE, 2013
Neurotrophins and modifiers of chromatin acetylation and deacetylation participate in regulation of transcription during neuronal maturation and maintenance.
Samira Chandwani, Serene Keilani, Maitane Ortiz-Virumbrales, Andrika Morant, Steve Bezdecny, Michelle E Ehrlich   +5 more
doaj   +1 more source

Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4 [PDF]

Molecular and Cellular Biology, 2008
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates histone deacetylase 4 (HDAC4), a class IIa HDAC, resulting in the cytosolic accumulation of HDAC4 and the derepression of the transcription factor myocyte enhancer factor 2. Phosphorylation by CaMKII requires docking of the kinase to a specific domain of HDAC4 not present in other ...
Johannes, Backs, Thea, Backs, Svetlana, Bezprozvannaya, Timothy A, McKinsey, Eric N, Olson   +4 more
openaire   +2 more sources