Results 31 to 40 of about 155,197 (274)
MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. [PDF]
Int J Mol Sci, 2016 Chondrocyte hypertrophy, regulated by Runt-related transcription factor 2 (RUNX2) and matrix metalloproteinase 13 (MMP13), is a crucial step in cartilage degeneration and osteoarthritis (OA) pathogenesis. We previously demonstrated that microRNA-381 (miR-381) promotes MMP13 expression during chondrogenesis and contributes to cartilage degeneration ...
Chen W +8 more
europepmc +4 more sources
Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo
Molecular Medicine, 2020 Background HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression.
Lilan Gao +5 more
doaj +1 more source
Valproate alters dopamine signaling in association with induction of Par-4 protein expression. [PDF]
PLoS ONE, 2012 Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA), a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC) inhibitor ...
Saebom Lee +7 more
doaj +1 more source
Sci, 2022 Artesunate (ART), a plant based semi-synthetic antimalarial drug, is emerging as a new class of effective cancer chemotherapeutics. However, the dosage of ART required to have an anti-cancer effect on cancer cells is greater than that needed to ...
Asif Raza +3 more
doaj +1 more source
Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death [PDF]
The Journal of Neuroscience, 2005 Histone deacetylase 4 (HDAC4) undergoes signal-dependent shuttling between the cytoplasm and nucleus, which is regulated in part by calcium/calmodulin-dependent kinase (CaMK)-mediated phosphorylation. Here, we report that HDAC4 intracellular trafficking is important in regulating neuronal cell death.
Timothy A, Bolger, Tso-Pang, Yao
openaire +2 more sources
Translational Oncology, 2016 Background: The current chemotherapeutic outcomes for hepatocellular carcinoma (HCC) are not encouraging, and long-term survival of this patient group remains poor.
Jing Liu +9 more
doaj +1 more source
Histone Deacetylase 4 Possesses Intrinsic Nuclear Import and Export Signals [PDF]
Molecular and Cellular Biology, 2001 Nucleocytoplasmic trafficking of histone deacetylase 4 (HDAC4) plays an important role in regulating its function, and binding of 14-3-3 proteins is necessary for its cytoplasmic retention. Here, we report the identification of nuclear import and export sequences of HDAC4.
A H, Wang, X J, Yang
openaire +2 more sources
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]
, 2017 Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello +3 more
core +1 more source
Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
Haematologica, 2010 Background The clinical use of chromatin-modulating drugs, such as histone deacetylase inhibitors, for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last few years.
Marije Bartels +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
doaj +1 more source