Results 61 to 70 of about 155,197 (274)

Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production

Molecular Biology of the Cell, 2014
Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immunometabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysaccharide (LPS).
Wang, Bin, Liu, Ting-yu, Lai, Chun-Hsiang, Rao, Yan-hua, Choi, Moon-Chang, Chi, Jen-Tsan, Dai, Jian-wu, Rathmell, Jeffrey C., Yao, Tso-Pang   +8 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal [PDF]

, 2018
Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases.
Battistelli, Cecilia, Bordoni, Veronica, DE TURRIS, Valeria, Domenici, Alessandro, Mai, Antonello, Manzione, Andrea, Mene', Paolo, Moioli, Alessandra, Noce, Valeria, Palladino, Marco, Rossi, Lucia, Strippoli, Raffaele, Tripodi, Marco, Valente, Sergio, Zwergel, Clemens   +14 more
core   +1 more source

The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells [PDF]

FEBS Letters, 2006
MicroRNAs (miRNA) are short RNA molecules regulating the expression of specific mRNAs. We investigated the expression pattern and potential targets of mouse miR‐140 and found that miR‐140 is specifically expressed in cartilage tissues of mouse embryos during both long and flat bone development.
Tuddenham, Lee, Wheeler, Guy, Ntouniafousara, Sofia, Waters, Jasmine, Hajihosseini, Mohammad, Clark, Ian, Dalmay, Tamas   +6 more
openaire   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification

Experimental and Molecular Medicine, 2019
Aortic valve calcification develops in patients with chronic kidney disease who have calcium and phosphate metabolic disorders and poor prognoses. There is no effective treatment except valve replacement. However, metabolic disorders put patients at high
Jia Gu, Yan Lu, Menqing Deng, Ming Qiu, Yunfan Tian, Yue Ji, Pengyu Zong, Yongfeng Shao, Rui Zheng, Bin Zhou, Xiangqing Kong, Wei Sun   +11 more
doaj   +1 more source

Targeting N-Myristoylation Through NMT2 Prevents Cardiac Hypertrophy and Heart Failure

JACC: Basic to Translational Science, 2023
Summary: Protein diversity can increase via N-myristoylation, adding myristic acid to an N-terminal glycine residue. In a murine model of pressure overload, knockdown of cardiac N-myristoyltransferase 2 (NMT2) by adeno-associated virus 9 exacerbated ...
Yusuke Tomita, MD, Fumiya Anzai, MD, PhD, Tomofumi Misaka, MD, PhD, Ryo Ogawara, MD, Shohei Ichimura, MD, Kento Wada, MD, PhD, Yusuke Kimishima, MD, PhD, Tetsuro Yokokawa, MD, PhD, Takafumi Ishida, MD, PhD, Yasuchika Takeishi, MD, PhD   +9 more
doaj   +1 more source

Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification. [PDF]

EMBO Rep, 2017
AbstractA pathologic osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) promotes arterial calcifications, a process associated with significant morbidity and mortality. The molecular pathways promoting this pathology are not completely understood.
Abend A, Shkedi O, Fertouk M, Caspi LH, Kehat I.   +4 more
europepmc   +4 more sources

Epigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection. [PDF]

, 2017
In pulmonary tuberculosis (TB), the inflammatory immune response against Mycobacterium tuberculosis (Mtb) is associated with tissue destruction and cavitation, which drives disease transmission, chronic lung disease, and mortality.
Alland, Aung, Azad, Bannister, Barchowsky, Bell, Bird, Brilha, Chen, Chernov, Choudhary, Culley, de Ruijter, Dobaczewski, Elkington, Feng, Goldberg, Green, Gregoire, Gregoretti, Horiuchi, Jaspers, Khan, Kim, Kleinsteuber, Kubler, Kumar, Lee, Loffek, Lu, Maciejewska-Rodrigues, Majeed, McErlean, McGarry Houghton, Michael, Mittelstadt, Mortaz, Moser, Nasu, Omanakuttan, Ong, Ong, Roger, Shahbazian, Shammari, Singh, Swamy, Tezera, Thuong, Wallis, Wang, Wang, Wolffe   +52 more
core   +2 more sources

Histone deacetylase 4 is required for TGFβ1-induced myofibroblastic differentiation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
Transforming Growth Factor beta1 (TGFbeta1) is a crucial cytokine triggering myofibroblastic (MF) differentiation, a process involved in tissue healing as well as in pathologic conditions such as fibrosis and cancer. Together with cell shape modifications, TGFbeta1-mediated differentiation of fibroblasts into myofibroblasts is characteristically ...
Glenisson, Wendy, Castronovo, Vincenzo, Waltregny, David   +2 more
openaire   +3 more sources