The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer [PDF]
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
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Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean [PDF]
Plants, 2022 Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu +7 more
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Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2022 Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka +4 more
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A new role for histone demethylases in the maintenance of plant genome integrity [PDF]
eLife, 2020 Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes.
Javier Antunez-Sanchez +17 more
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Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence [PDF]
BMC Evolutionary Biology, 2008 Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing ...
Zhou Xiaofan, Ma Hong
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Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities [PDF]
Current Issues in Molecular BiologyHistone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu +3 more
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Histone Demethylases as Counterbalance to H3K27me3 Silencing in Plants [PDF]
iScience, 2020 Summary: The universal importance of epigenetic regulation has become explicit over the last decade. There is now a detailed understanding of the molecular signatures and chromatin-modifying enzymes determining epigenetic regulation.
Pedro Crevillén
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Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis [PDF]
Frontiers in Plant Science, 2020 Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression.
Jinfeng Wu +11 more
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Histone demethylases in autophagy and inflammation [PDF]
Cell Communication and SignalingAutophagy dysfunction is associated with changes in autophagy-related genes. Various factors are connected to autophagy, and the mechanism regulating autophagy is highly complicated. Epigenetic changes, such as aberrant expression of histone demethylase,
Yaoyao Ma +15 more
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JmjC histone demethylases act as chromatin oxygen sensors [PDF]
Molecular & Cellular Oncology, 2019 Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation.
Michael Batie, Sonia Rocha
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