The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer [PDF]
Frontiers in Immunology, 2022 Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses ...
Jia Yang +4 more
doaj +3 more sources
A new role for histone demethylases in the maintenance of plant genome integrity [PDF]
eLife, 2020 Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes.
Javier Antunez-Sanchez +17 more
doaj +3 more sources
Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis [PDF]
Frontiers in Plant Science, 2020 Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression.
Jinfeng Wu +11 more
doaj +3 more sources
The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. [PDF]
Blood, 2019 KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity
Agger K +5 more
europepmc +4 more sources
JmjC histone demethylases act as chromatin oxygen sensors [PDF]
Molecular & Cellular Oncology, 2019 Oxygen sensing is important in physiology but also in disease. We find that hypoxia (oxygen deficiency) triggers rapid and hypoxia-inducible factor (HIF)-independent histone methylation changes which are reversible upon reoxygenation.
Michael Batie, Sonia Rocha
doaj +3 more sources
The emerging role of histone demethylases in renal cell carcinoma [PDF]
Journal of Kidney Cancer and VHL, 2017 Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood.
Xiaoqiang Guo, Qiaoxia Zhang
doaj +3 more sources
Histone demethylases in the regulation of immunity and inflammation. [PDF]
Cell Death Discov, 2023 Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage.
Qu L +10 more
europepmc +2 more sources
Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean [PDF]
Plants, 2022 Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of ...
Mengshi Liu +7 more
doaj +2 more sources
Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2022 Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC).
Takashi Maruoka +4 more
doaj +2 more sources
Cells, 2022 Epigenetic regulation of gene expression is crucial to the determination of cell fate in development and differentiation, and the Polycomb (PcG) and Trithorax (TrxG) groups of proteins, acting antagonistically as complexes, play a major role in this ...
Joyce Taylor-Papadimitriou +1 more
doaj +2 more sources