Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation [PDF]
IUCrJ, 2014 Iron(II) and 2-oxoglutarate (2OG)-dependent dioxygenases involved in histone and DNA/RNA demethylation convert the cosubstrate 2OG and oxygen to succinate and carbon dioxide, resulting in hydroxylation of the methyl group of the substrates and subsequent
Cheng Dong +4 more
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Histone H4K20 Demethylation by Two hHR23 Proteins [PDF]
Cell Reports, 2020 Summary: Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown.
Xiongwen Cao +13 more
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LSD1: more than demethylation of histone lysine residues [PDF]
Experimental & Molecular Medicine, 2020 AbstractLysine-specific histone demethylase 1 (LSD1) represents the first example of an identified nuclear protein with histone demethylase activity. In particular, it plays a special role in the epigenetic regulation of gene expression, as it removes methyl groups from mono- and dimethylated lysine 4 and/or lysine 9 on histone H3 (H3K4me1/2 and ...
Bruno Perillo +3 more
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Iron drives anabolic metabolism through active histone demethylation and mTORC1. [PDF]
Nat Cell Biol, 2023 Abstract All living cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here, we report a universal eukaryotic pathway for iron sensing in which molecular iron is required to sustain active histone demethylation and maintain the ...
Shapiro JS +27 more
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Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Epigenetic modifications of chromatin are emerging as important regulatory mechanisms of many nuclear processes. Numerous proteins have been identified that mediate these modifications in a dynamic manner.
Adam Burton +4 more
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Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae. [PDF]
Genetics, 2019 Saatchi F, Kirchmaier AL.
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Lysine-241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4-Catalysed Histone Demethylation. [PDF]
Chembiochem, 2018 Hancock RL +6 more
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Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation. [PDF]
Oncotarget, 2017 Shen Y +5 more
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dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing [PDF]
Genes & Development, 2008 Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2).
Anna Lagarou +6 more
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The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. [PDF]
PLoS Genetics, 2012 Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia.
Dongning Pan +6 more
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