LSD1 demethylates histone and non-histone proteins [PDF]
Epigenetics, 2009 One of the key breakthroughs in the epigenetics/chromatin field in the last several years was the identification of enzymes capable of removing the methyl group from methylated lysines in histone proteins. Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and ...
Thomas B, Nicholson, Taiping, Chen
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Functions and Interactions of Mammalian KDM5 Demethylases
Frontiers in Genetics, 2022 Mammalian histone demethylases of the KDM5 family are mediators of gene expression dynamics during developmental, cellular differentiation, and other nuclear processes.
Egor Pavlenko +4 more
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Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
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Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]
PLoS ONE, 2010 Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Phillip Hahn +9 more
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Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
Cell Reports, 2021 Summary: Regulatory T (Treg) cells play crucial roles in suppressing deleterious immune response. Here, we investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifying ...
Jun Li +9 more
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Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]
, 2020 Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert +58 more
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Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1 [PDF]
, 2007 In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two
Abdelhalim Boukaba +48 more
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Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro. [PDF]
PLoS ONE, 2013 Posttranslational modifications (PTMs) of the histone H3 tail such as methylation, acetylation and phosphorylation play important roles in epigenetic signaling.
Brian Lohse +6 more
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Histone Demethylation and Timely DNA Replication [PDF]
Molecular Cell, 2010 It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.
Gerace, Erica L., Moazed, Danesh
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Human SCNT Gets a Boost from Histone Demethylation [PDF]
Cell Stem Cell, 2015 Human somatic cell nuclear transfer (SCNT) holds great potential in regenerative medicine; however, its applicability has been limited by great variability in reprogramming efficiencies. A new study in this issue of Cell Stem Cell reports a simple way to expand human SCNT to hard-to-reprogram oocytes (Chung et al., 2015).
Alessia Deglincerti, Ali H. Brivanlou
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