Results 41 to 50 of about 60,846 (261)

Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. [PDF]

PLoS ONE, 2015
Epigenetic reprogramming is exemplified by the remarkable changes observed in cellular differentiation and X-chromosome inactivation (XCI) in mammalian female cells.
Yasunao F Kamikawa, Mary E Donohoe
doaj   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain, AJ Boivin, B Hendrich, BC Richardson, C Anacleto, C Grunau, CA Eads, E Bair, E Papouli, EE Cameron, F Lyko, G Egger, G Gifford, G Strathdee, G Strathdee, HG Chang, J Hall, J M Teodoridis, J Tra, JA Plumb, JF Costello, JG Herman, JM Teodoridis, JM Teodoridis, JP Issa, K Yamashita, L Zhang, LA Loeb, M Daskalakis, M Esteller, M Esteller, M Esteller, M Lachner, M Toyota, ME Valk-Lingbeek, MF Paz, MF Paz, MM Gottesman, MS Soengas, NP Bhattacharyya, PJ Johnson, PM Warnecke, R Agarwal, R Brown, R Brown, R M Glasspool, S Fulda, SH Wei, SH Wei, SL Gerson, SM Taylor, SW Lowe, T Taniguchi, T Ushijima, TH Huang, W Fischle, Y Pommier, Z Xiong   +57 more
core   +2 more sources

LSD1 and the chemistry of histone demethylation [PDF]

Current Opinion in Chemical Biology, 2007
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the ...
Jeffrey C, Culhane, Philip A, Cole
openaire   +2 more sources

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

Cell Reports, 2014
Summary: Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear.
Changmeng Cai, Housheng Hansen He, Shuai Gao, Sen Chen, Ziyang Yu, Yanfei Gao, Shaoyong Chen, Mei Wei Chen, Jesse Zhang, Musaddeque Ahmed, Yang Wang, Eric Metzger, Roland Schüle, X. Shirley Liu, Myles Brown, Steven P. Balk   +15 more
doaj   +1 more source

Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]

, 2017
Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina, Heras Garcia, Sonia, Smits, Katrien, Van Soom, Ann   +3 more
core   +1 more source

Removal of H3K27me3 by JMJ Proteins Controls Plant Development and Environmental Responses in Arabidopsis

Frontiers in Plant Science, 2021
Trimethylation of histone H3 lysine 27 (H3K27me3) is a highly conserved repressive histone modification that signifies transcriptional repression in plants and animals.
Nobutoshi Yamaguchi
doaj   +1 more source

Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study. [PDF]

PLoS ONE, 2011
Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is a flavin-dependent amine oxidase which specifically demethylates mono- or dimethylated H3K4 and H3K9 via a redox process. It participates in a broad spectrum of biological
Xiangqian Kong, Sisheng Ouyang, Zhongjie Liang, Junyan Lu, Liang Chen, Bairong Shen, Donghai Li, Mingyue Zheng, Keqin Kathy Li, Cheng Luo, Hualiang Jiang   +10 more
doaj   +1 more source

JmjC-domain-containing proteins and histone demethylation

Nature Reviews Genetics, 2006
Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system.
Klose, R, Kallin, E, Zhang, Y
openaire   +2 more sources

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis

Stem Cell Reports, 2018
Summary: Histone H3 lysine 9 (H3K9) methylation is unevenly distributed in mammalian chromosomes. However, the molecular mechanism controlling the uneven distribution and its biological significance remain to be elucidated.
Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi, Katsuhiko Shirahige, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana   +13 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources