Results 1 to 10 of about 287,782 (136)

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]

PLoS ONE, 2011
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Tobias D Schneider, Jose M Arteaga-Salas, Edith Mentele, Robert David, Dario Nicetto, Axel Imhof, Ralph A W Rupp   +6 more
doaj   +15 more sources

Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer [PDF]

Frontiers in Molecular Biosciences
BackgroundProstate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response.
XiaoFeng He, QinTao Ge, QinTao Ge, WenYang Zhao, Chao Yu, HuiMing Bai, XiaoTong Wu, Jing Tao, WenHao Xu, WenHao Xu, Yunhua Qiu, Lei Chen, JianFeng Yang   +12 more
doaj   +2 more sources

Integration of Microarray and Single-Cell RNA-Seq Data and Machine Learning Allows the Identification of Key Histone Modification Gene Changes in Spermatogonial Stem Cells [PDF]

Biology
Histone modifications play a critical role in regulating gene expression and maintaining the functionality of spermatogonial stem cells (SSCs), which are essential for male fertility and spermatogenesis. In this study, we integrated microarray and single-
Ali Shakeri Abroudi, Hossein Azizi, Melika Djamali, Ali Qorbanee, Thomas Skutella   +4 more
doaj   +2 more sources

Optimized Tensor Decomposition and Principal Component Analysis Outperforming State-of-the-Art Methods When Analyzing Histone Modification Chromatin Immunoprecipitation Profiles

Algorithms, 2023
It is difficult to identify histone modification from datasets that contain high-throughput sequencing data. Although multiple methods have been developed to identify histone modification, most of these methods are not specific to histone modification ...
Turki Turki, Sanjiban Sekhar Roy, Y.-H. Taguchi   +2 more
doaj   +1 more source

Histone Modifications in Acute Kidney Injury

Kidney Diseases, 2022
Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial.
Jun Wang, Fengchen Shen, Feng Liu, Shougang Zhuang   +3 more
doaj   +1 more source

The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review

Frontiers in Physiology, 2023
Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
doaj   +1 more source

The Regulation and Function of Histone Crotonylation

Frontiers in Cell and Developmental Biology, 2021
Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone ...
Angeliki Ntorla, Joseph Robert Burgoyne
doaj   +1 more source

Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Cell Discovery, 2021
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding ...
Kyle Delaney, Minjia Tan, Zhesi Zhu, Jinjun Gao, Lunzhi Dai, Sunjoo Kim, Jun Ding, Maomao He, Levon Halabelian, Lu Yang, Prabakaran Nagarajan, Mark Robert Parthun, Sangkyu Lee, Saadi Khochbin, Yujun George Zheng, Yingming Zhao   +15 more
doaj   +1 more source

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
core   +3 more sources

Relationship between histone demethylase LSD family and development and prognosis of gastric cancer

Frontiers in Immunology, 2023
Objectiveto elucidate the correlation between histone demethylase and gastric cancerResearch objecthistone demethylase and gastric cancerResultsAs one of the important regulatory mechanisms in molecular biology and epigenetics, histone modification plays
Liyan Dong, Jiaxing Zhu, Anyi Deng, Junping Wei, Jiawei Li, Xinru Mao, Zhenghu Jia, Zhenghu Jia, Zhenghu Jia   +8 more
doaj   +1 more source