Results 11 to 20 of about 287,931 (282)
Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
openaire +2 more sources
Histone onco-modifications [PDF]
Oncogene, 2011 Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis.
J, Füllgrabe, E, Kavanagh, B, Joseph
openaire +2 more sources
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources
Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. [PDF]
PLoS ONE, 2016 Tumor cells become resistant after long-term use of anti-VEGF (vascular endothelial growth factor) agents. Our previous study shows that treatment with a VEGF inhibitor (VEGF-Trap) facilitates to develop tumor resistance through regulating angiogenesis ...
Dong Li +10 more
doaj +1 more source
Transcription factors direct epigenetic reprogramming at specific loci in human cancers
Frontiers in Genetics, 2023 The characterization of epigenetic changes during cancer development and progression led to notable insights regarding the roles of cancer-specific epigenetic reprogramming.
Han Jiang, Guoxin Li
doaj +1 more source
BMC Genomics, 2019 Background Defining histone modification at single-nucleosome resolution provides accurate epigenomic information in individual nucleosomes. However, most of histone modification data deposited in current databases, such as ENCODE and Roadmap, have low ...
Daoshan Zheng +3 more
doaj +1 more source
Temporal and spatial distribution of histone acetylation in mouse molar development [PDF]
PeerJHistone acetylation is one of the most widely studied histone modification, regulating a variety of biological activities like organ development and tumorigenesis. However, the role of histone acetylation in tooth development is poorly understood.
Wen Du +4 more
doaj +2 more sources
Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila
Cells, 2022 Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian +4 more
doaj +1 more source
BMC Genomics, 2011 Background In parallel with the quick development of high-throughput technologies, in vivo (vitro) experiments for genome-wide identification of protein-DNA interactions have been developed.
Wang Junbai
doaj +1 more source
Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification [PDF]
, 2016 The photoreceptor UV RESISTANCE LOCUS 8 (UVR8) specifically mediates photomorphogenic responses to UV-B wavelengths. UVR8 acts by regulating transcription of a set of genes, but the underlying mechanisms are unknown. Previous research indicated that UVR8
Herzyk, Pawel +2 more
core +1 more source