Results 21 to 30 of about 287,931 (282)
SnapShot: Histone Modifications
Cell, 2014 Histone proteins are decorated by a variety of protein posttranslational modifications called histone marks that modulate chromatin structure and function, contributing to the cellular gene expression program. This SnapShot summarizes the reported human, mouse, and rat histone marks, including recently identified lysine acylation marks.
Huang, He +4 more
openaire +2 more sources
Histone Modifications and Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
openaire +2 more sources
Scientific Reports, 2023 Human epidermal growth factor receptor 2 (HER2) plays an important role in diagnosis and treatment of breast cancer (BRCA). The histone modification has been found to be related to the progression of cancer.
Jia Li, Jingchun Yao, Liqiang Qi
doaj +1 more source
Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +2 more sources
BMC Biology, 2004 Background In mammals, there is evidence suggesting that methyl-CpG binding proteins may play a significant role in histone modification through their association with modification complexes that can deacetylate and/or methylate nucleosomes in the ...
Canfield Theresa K +6 more
doaj +1 more source
Histone modifications centric-regulation in osteogenic differentiation
Cell Death Discovery, 2021 Histone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters.
Kun Li, Jinxiang Han, Ziqiang Wang
doaj +1 more source
ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect, Bactroceradorsalis
Frontiers in Genetics, 2023 Introduction: While it has been suggested that histone modifications can facilitate animal responses to rapidly changing environments, few studies have profiled whole-genome histone modification patterns in invasive species, leaving the regulatory ...
Yan Zhao +3 more
doaj +1 more source
Readers of histone modifications [PDF]
Cell Research, 2011 Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of
Miyong, Yun +3 more
openaire +2 more sources
Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core +3 more sources
Crosstalk among Histone Modifications [PDF]
Cell, 2008 Histone modifications play a complex role in the regulation of transcription. Recent studies (Duncan et al., 2008; Lee et al., 2007; Li et al., 2008) reveal that regulation of histone modifications can be functionally linked to reinforce the activation or repression of gene expression.
Suganuma, Tamaki, Workman, Jerry L.
openaire +2 more sources