The function of histone methylation and acetylation regulators in GBM pathophysiology
Frontiers in Oncology, 2023 Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly immunosuppressive tumor microenvironment, and nearly universal recurrence.
Colin McCornack +7 more
doaj +1 more source
The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
doaj +1 more source
GoPeaks: histone modification peak calling for CUT&Tag
Genome Biology, 2022 Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone modifications, offering improved sensitivity and decreased cost compared with ChIP-seq.
William M. Yashar +8 more
doaj +1 more source
Combinatorial Pattern of Histone Modifications in Exon Skipping Event
Frontiers in Genetics, 2019 Histone modifications are associated with alternative splicing. It has been suggested that histone modifications act in combinational patterns in gene expression regulation.
Wei Chen +4 more
doaj +1 more source
BPA-Induced Deregulation of Epigenetic Patterns: Effects on Female Zebrafish Reproduction [PDF]
, 2016 Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms.
Carnevali, Oliana +6 more
core +1 more source
SnapShot: Histone Modifications
Cell, 2014 Histone proteins are decorated by a variety of protein posttranslational modifications called histone marks that modulate chromatin structure and function, contributing to the cellular gene expression program. This SnapShot summarizes the reported human, mouse, and rat histone marks, including recently identified lysine acylation marks.
Huang, He +4 more
openaire +2 more sources
Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. [PDF]
, 2019 Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism's complex life cycle.
Cook, Kate +4 more
core +2 more sources
Epigenetics, 2023 Histones are subjected to extensive covalent modifications that affect inter-nucleosomal interactions as well as alter chromatin structure and DNA accessibility.
Yang Yu +4 more
doaj +1 more source
Readers of histone modifications [PDF]
Cell Research, 2011 Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of
Miyong, Yun +3 more
openaire +2 more sources
PTMViz: a tool for analyzing and visualizing histone post translational modification data
BMC Bioinformatics, 2021 Background Histone post-translational modifications (PTMs) play an important role in our system by regulating the structure of chromatin and therefore contribute to the regulation of gene and protein expression. Irregularities in histone PTMs can lead to
Kevin Chappell +6 more
doaj +1 more source