Results 221 to 230 of about 5,681,501 (240)

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +1 more source

Histone post-translational modifications — cause and consequence of genome function

Nature Reviews Genetics, 2022
Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-templated processes at the molecular level.
Robert Schneider, Gonzalo Millán-Zambrano, Andrew Bannister   +2 more
exaly   +3 more sources

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Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders

Journal of Biosciences, 2020
Abdollah Allahverdi, Javad Zahiri, Shahin Ramazi   +2 more
exaly  

Recombinant antibodies to histone post-translational modifications

Nature Methods, 2013
Shohei Koide, Krzysztof Krajewski, Brian D Strahl   +2 more
exaly  

Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer

Cancers, 2018
David Corujo, Marcus Buschbeck
exaly  

Histone modifications in mitosis

Nature Reviews Molecular Cell Biology, 2014
Katharine Wrighton
exaly  

Combined bottom-up and top-down mass spectrometry analyses of the pattern of post-translational modifications of linker histone H1

Journal of Proteomics, 2012
Jordi Bernués, Ernest Giralt i Lledó, Marta Vilaseca   +2 more
exaly  

Molecular mechanisms and potential functions of histone demethylases

Nature Reviews Molecular Cell Biology, 2012
Kristian Helin
exaly