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Histones and histone variant families in prokaryotes. [PDF]
Nat CommunAbstractHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent sequences.
Schwab S +8 more
europepmc +6 more sources
Histone variants at a glance [PDF]
Journal of Cell Science, 2021 ABSTRACT Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1.
Paul B. Talbert, Steven Henikoff
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Histone Variants and Epigenetics [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin ...
Steven, Henikoff, M Mitchell, Smith
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H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity
Plant Communications, 2020 The eukaryotic nucleosome prevents access to the genome. Convergently evolving histone isoforms, also called histone variants, form diverse families that are enriched over distinct features of plant genomes.
Bingkun Lei, Frédéric Berger
doaj +1 more source
Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis
Frontiers in Oncology, 2022 Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Ting Wen, Qiao Yi Chen
doaj +1 more source
Communications Biology, 2022 The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
Gurdeep Singh +18 more
doaj +1 more source
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]
, 2005 The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C. +8 more
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Histone variants: deviants? [PDF]
Genes & Development, 2005 Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns.
Rohinton T, Kamakaka, Sue, Biggins
openaire +2 more sources
BMC Plant Biology, 2009 Background Histone modifications and histone variants are of importance in many biological processes. To understand the biological functions of the global dynamics of histone modifications and histone variants in higher plants, we elucidated the variants
Lam Hon-Ming +6 more
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Epigenetic aberrations and cancer [PDF]
, 2006 The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core +3 more sources