Biology Open, 2019 Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone ...
Yukimasa Shibata +2 more
doaj +1 more source
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans [PDF]
, 2019 Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress.
Cedric A. Brimacombe (6866186) +28 more
core +1 more source
Cleavage-embryo genes and transposable elements are regulated by histone variant H2A.X
The Journal of Reproduction and Development, 2021 During mammalian preimplantation development, stimulation of zygotic genome activation (ZGA) and transposable elements (TEs) shapes totipotency profiling.
Kai-yi SUN +5 more
doaj +1 more source
Histone Variants in Metazoan Development [PDF]
Developmental Cell, 2010 Embryonic development is regulated by both genetic and epigenetic mechanisms, with nearly all DNA-templated processes influenced by chromatin architecture. Sequence variations in histone proteins, core components of chromatin, provide a means to generate diversity in the chromatin structure, resulting in distinct and profound biological outcomes in the
Banaszynski, Laura A. +2 more
openaire +2 more sources
Histone variants in pluripotency and disease [PDF]
Development, 2013 Most histones are assembled into nucleosomes during replication to package genomic DNA. However, several variant histones are deposited independently of replication at particular regions of chromosomes. Such histone variants include cenH3, which forms the nucleosomal foundation for the centromere, and H3.3, which replaces histones that are lost during ...
Peter J, Skene, Steven, Henikoff
openaire +2 more sources
Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling [PDF]
, 2009 The (H3-H4)(2) histone tetramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disassembly and positioning of nucleosomes.
Ward, Richard +7 more
core +1 more source
Improved tools for efficient mapping of fission yeast genes:identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1 [PDF]
, 2008 Fission yeast genes identified in genetic screens are usually cloned by transformation of mutants with plasmid libraries. However, for some genes this can be difficult, and positional cloning approaches are required.
Sawin, Kenneth E +3 more
core +1 more source
Focus on histone variant H2AX: To be or not to be [PDF]
FEBS Letters, 2010 Phosphorylation of histone variant H2AX at serine 139, named γH2AX, has been widely used as a sensitive marker for DNA double‐strand breaks (DSBs). γH2AX is required for the accumulation of many DNA damage response (DDR) proteins at DSBs. Thus it is believed to be the principal signaling protein involved in DDR and to play an important role in DNA ...
Yuan, Jingsong +2 more
openaire +2 more sources
Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. [PDF]
, 2008 The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine ...
Villar-Garea, Ana +3 more
core +2 more sources
Functional Redundancy and Feedback Regulation between Canonical Histone H3 and Variant Histone H3.3 in Drosophila [PDF]
, 2019 Animal cell chromatin contains two types of histones: canonical and variant. Although canonical and variant histones have similar structures, their expression and incorporation into chromatin are regulated differently.
Kwon, Esther
core +1 more source