Results 11 to 20 of about 723,033 (304)

Histone profiling reveals the H1.3 histone variant as a prognostic biomarker for pancreatic ductal adenocarcinoma [PDF]

BMC Cancer, 2017
Background Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood.
Monika Bauden, Theresa Kristl, Agata Sasor, Bodil Andersson, György Marko-Varga, Roland Andersson, Daniel Ansari   +6 more
doaj   +2 more sources

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

Chromosome Research, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3.
Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H. A., Copenhaver, G. P., DeLuca, J. G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, Stephen, Heun, P., Hirota, T., Jansen, L. E. T., Karpen, G., Kops, G. J. P. L., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D., Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O’Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K., Cleveland, D. W.   +56 more
openaire   +13 more sources

Histone variants at a glance [PDF]

Journal of Cell Science, 2021
ABSTRACT Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1.
Paul B. Talbert, Steven Henikoff
openaire   +2 more sources

Histone variant H2A.W7 represses meiotic crossover formation in <i>Arabidopsis</i> heterochromatin. [PDF]

Proc Natl Acad Sci U S A
In eukaryotic genomes, DNA is packaged into nucleosomes to form chromatin. The incorporation of canonical or variant histones into nucleosomes confers different properties and influences chromatin structure to regulate cellular processes, including ...
Kuo P, Tock AJ, Liu X, Topp SD, Zhong Z, Henderson IR, Lambing C, Lambing C.   +7 more
europepmc   +2 more sources

Histones and histone variant families in prokaryotes. [PDF]

Nat Commun
AbstractHistones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit different DNA binding properties, in addition to highly divergent sequences.
Schwab S, Hu Y, van Erp B, Cajili MKM, Hartmann MD, Hernandez Alvarez B, Alva V, Boyle AL, Dame RT.   +8 more
europepmc   +7 more sources

Histone Variants and Epigenetics [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin ...
Steven, Henikoff, M Mitchell, Smith
openaire   +2 more sources

Histone Variant H2A.Z Enhances Histone and Nucleosome Dynamics. [PDF]

Mol Cell Proteomics
Interchanging canonical histone H2A with variant H2A.Z in chromatin complexes is vital for the proper regulation of transcription, DNA damage repair, and centromere maintenance. However, the physical mechanisms underlying functional differences between H2A and H2A.Z complexes are unclear.
Dias JK, Dias PS, Alakenova R, Mariasoosai C, Claridy C, Gazi S, Torabifard H, D'Arcy S.   +7 more
europepmc   +3 more sources

H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity

Plant Communications, 2020
The eukaryotic nucleosome prevents access to the genome. Convergently evolving histone isoforms, also called histone variants, form diverse families that are enriched over distinct features of plant genomes.
Bingkun Lei, Frédéric Berger
doaj   +1 more source

Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis

Frontiers in Oncology, 2022
Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Ting Wen, Qiao Yi Chen
doaj   +1 more source

Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice

Communications Biology, 2022
The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic   +18 more
doaj   +1 more source