Results 21 to 30 of about 723,033 (304)

A histone methyltransferase modulates antigenic variation in African trypanosomes [PDF]

, 2008
To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Janzen, Christian J., Figueiredo Luisa M, Cross, George A. M., Figueiredo, Luisa M., Cross George A.M, Luisa M Figueiredo, Christian J Janzen, George A M Cross, Janzen Christian J   +8 more
core   +1 more source

Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications

BMC Plant Biology, 2009
Background Histone modifications and histone variants are of importance in many biological processes. To understand the biological functions of the global dynamics of histone modifications and histone variants in higher plants, we elucidated the variants
Lam Hon-Ming, Sun Sai-Ming, Wang Chunmei, Tsai Sau-Na, Yuan Tiezheng, Wu Tao, Ngai Sai-Ming   +6 more
doaj   +1 more source

Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]

Molecular Endocrinology, 2005
Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
openaire   +2 more sources

HistoneDB 2.0: a histone database with variants—an integrated resource to explore histones and their variants [PDF]

Database, 2016
Compaction of DNA into chromatin is a characteristic feature of eukaryotic organisms. The core (H2A, H2B, H3, H4) and linker (H1) histone proteins are responsible for this compaction through the formation of nucleosomes and higher order chromatin aggregates.
Eli J. Draizen, Alexey K. Shaytan, Leonardo Mariño-Ramírez, Paul B. Talbert, David Landsman, Anna R. Panchenko   +5 more
openaire   +3 more sources

The Role of MacroH2A Histone Variants in Cancer [PDF]

Cancers, 2021
The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. Among epigenetic mechanisms, the replacement of replication-coupled histones with histone variants is the least ...
Chen-Jen Hsu, Oliver Meers, Marcus Buschbeck, Florian H. Heidel   +3 more
openaire   +4 more sources

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]

, 2011
Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew, El Mkami, Hassane, Nicola Wiechens, Bowman, A., Vijender Singh, Andrew Bowman, David George Norman, Ward, Richard, Singh, Vijender, Owen-Hughes, Tom; id_orcid, El-Mkami, Hassane, Richard Ward, Hassane El-Mkami, Wiechens, Nicola, Norman, David George, Owen-Hughes, Tom, Tom Owen-Hughes, El Mkami, Hassane; id_orcid   +17 more
core   +1 more source

Histone variants and cellular plasticity [PDF]

Trends in Genetics, 2015
The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation.
Santoro, Stephen W, Dulac, Catherine
openaire   +4 more sources

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells [PDF]

, 2012
This work was supported by the Medical Research Council, UK and by grant BB/H008500/1 from the BBSRC.The essential histone variant H2A.Z localises to both active and silent chromatin sites.
Eskeland, Ragnhild, Eskeland Ragnhild, Bickmore, Wendy A., Grimes Graeme R., Wendy A. Bickmore, Botting, Catherine H., Illingworth Robert S., Wendy A. Bickmore (42659), Illingworth, Robert S., Catherine H. Botting, Wendy A Bickmore, Graeme R Grimes, Ragnhild Eskeland, Robert S. Illingworth, Ragnhild Eskeland (22177), Graeme R. Grimes, Bickmore Wendy A., Catherine H Botting, Robert S. Illingworth (173072), Robert S Illingworth, Botting Catherine H., Graeme R. Grimes (164833), Grimes, Graeme R., Catherine H. Botting (173077)   +23 more
core   +2 more sources

Histone variant H2A.Z modulates nucleosome dynamics to promote DNA accessibility

Nature Communications, 2023
Here the authors show that H2A.Z histone variant incorporation reduces the nucleosomal barrier for transcription. Furthermore their simulations reveal that H2A.Z facilitates spontaneous DNA unwrapping from the histone octamer and enhances nucleosome ...
Shuxiang Li, Tiejun Wei, Anna R. Panchenko   +2 more
doaj   +1 more source

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription [PDF]

, 2014
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. However, our understanding of how histone modifications directly affect chromatin function remains limited.
Holzner, M. (M), Eleni Kallis, Holzner, M., Michaelis, J., Richter, F. (F) M. (M), Ryan, D. (D) P. (P), Feldmann, A. (A), Daniel P Ryan, Owen-Hughes, Tom; id_orcid, Kacem, S., Tropberger, Philipp, Di Cerbo, V., Bannister, A., Kallis, E. (E), Michaelis, Jens, Feldmann, A., Richter, Florian, Martin, Daujat, S. (Sylvain), Robert Schneider, Richter, F., Tropberger, P., Hoerner, Leslie, Richter, Florian Martin, Mittler, G. (G), Emilie Montellier, Di Cerbo, V. (V), Feil, Robert, Bannister, A. (A) J. (J), Vincenzo Di Cerbo, Ryan, D., Kallis, Eleni, Ryan, D. P., Di Cerbo, Vincenzo, Owen-Hughes, T. (T), Leslie Hoerner, Jens Michaelis, Kallis, E., Khochbin, S. (S), Saadi Khochbin, Schneider, Robert, Holzner, Monika, Monika Holzner, Feil, R. (R), Ryan, Daniel, P., Feldmann, Angelika, Tom Owen-Hughes, Owen-Hughes, T., Bannister, A. J., Feil, R., Mohn, F., Hoerner, L., Fabio Mohn, Richter, F. M., Montellier, E. (E), Mittler, G., Schuebeler, D., Montellier, Emilie, Mohn, F. (F), Tropberger, P. (P), Angelika Feldmann, Owen-Hughes, Tom, Kacem, Salim, Mittler, Gerhard, Daujat, Sylvain, Montellier, E., Schneider, R., Dirk Schuebeler, Schuebeler, D. (D), Bannister, Andrew J., Hoerner, L. (L), Khochbin, S., Schneider, R. (Robert), Schuebeler, Dirk, Salim Kacem, Philipp Tropberger, Mohn, Fabio, Florian Martin Richter, Kacem, S. (S), Sylvain Daujat, Ryan, Daniel P., Andrew J Bannister, Khochbin, Saadi, Gerhard Mittler, Michaelis, J. (J), Robert Feil, Daujat, S., Ryan, Daniel P, Bannister, Andrew J   +87 more
core   +1 more source