Results 1 to 10 of about 56,319 (181)

Latency: the hidden HIV-1 challenge [PDF]

Retrovirology, 2006
Eradication of HIV-1 from an infected individual cannot be achieved by current regimens. Viral reservoirs established early during the infection remain unaffected by anti-retroviral therapy for a long time and are able to replenish systemic infection ...
Marcello Alessandro
doaj   +5 more sources

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy? [PDF]

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Kobayashi-Ishihara M, Tsunetsugu-Yokota Y.   +1 more
europepmc   +2 more sources

Epitranscriptomic m⁶A modifications during reactivation of HIV-1 latency in CD4⁺ T cells. [PDF]

mBio
Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure.
Mishra T, Phillips S, Zhao Y, Wilms B, He C, Wu L.   +5 more
europepmc   +2 more sources

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation. [PDF]

J Virol
HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for
Chen C, Zhong Z, Zhang W, Xia B, Wu L, Liang L, Zhang Y, Zhang H, Zhang X, Pan T, Li L, Liu B.   +11 more
europepmc   +2 more sources

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells. [PDF]

Commun Biol, 2023
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Kobayashi-Ishihara M, Frazão Smutná K, Alonso FE, Argilaguet J, Esteve-Codina A, Geiger K, Genescà M, Grau-Expósito J, Duran-Castells C, Rogenmoser S, Böttcher R, Jungfleisch J, Oliva B, Martinez JP, Li M, David M, Yamagishi M, Ruiz-Riol M, Brander C, Tsunetsugu-Yokota Y, Buzon MJ, Díez J, Meyerhans A.   +22 more
europepmc   +2 more sources

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. [PDF]

PLoS Pathog, 2023
Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Hsieh E, Janssens DH, Paddison PJ, Browne EP, Henikoff S, OhAinle M, Emerman M.   +6 more
europepmc   +2 more sources

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency. [PDF]

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Crespo R, Ne E, Reinders J, Meier JIJ, Li C, Jansen S, Górska A, Koçer S, Kan TW, Doff W, Dekkers D, Demmers J, Palstra RJ, Rao S, Mahmoudi T.   +14 more
europepmc   +2 more sources

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency. [PDF]

Front Cell Infect Microbiol, 2023
Pasternak AO, Rohr O, Van Lint C, Kula-Pacurar A.   +3 more
europepmc   +2 more sources

Corrigendum: Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency. [PDF]

Front Cell Infect Microbiol, 2023
Pasternak AO, Rohr O, Van Lint C, Kula-Pacurar A.   +3 more
europepmc   +2 more sources

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3. [PDF]

Cell Commun Signal
Background Acquired immunodeficiency syndrome (AIDS) cannot be completely cured, and the main obstacle is the existence of viral reservoirs. However, we currently do not fully understand the molecular mechanisms by which HIV-1 latency is established and ...
Yang X, Zhu Y, Zhao X, Xun J, Wang X, Cheng Y, Xiong S, Yu X, Li S, Wang D, Hu Z, Shen Y, Jiang S, Lu H, Wang G, Zhu H.   +15 more
europepmc   +2 more sources