Results 141 to 150 of about 56,319 (181)

Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV-1 Latency Reversing Agents. [PDF]

ACS Med Chem Lett
Wang YK, Huang XS, Sun H, Ma MD, Yu HP, Hu W, Li ZY, Li Z, Luo RH, Tian RR, Xiao TF, Yang LM, Zheng YT, Li X.   +13 more
europepmc   +1 more source

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

, 2022
Prins H, Crespo R, Lungu C, Rao S, Li L, Overmars R, Papageorgiou G, Mueller Y, Hossain T, Kan T, Rijnders B, Bax H, van Gorp E, Nouwen J, de Vries-Sluijs T, Schurink C, de Mendonça Melo M, van Nood E, Colbers A, Burger D, Palstra R, van Kampen J, van de Vijver D, Mesplède T, Katsikis P, Gruters R, Koch B, Verbon A, Mahmoudi T, Rokx C.   +29 more
europepmc   +1 more source

Some MSM Blood Donors Move from a Lifetime Deferral to a One Year Ban “Finally” or “Not Good Enough”? [PDF]

, 2018
Printz, Heather
core   +1 more source

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Mechanisms of HIV-1 latency

AIDS, 1992
This review describes some of the virus-cell relationships that might contribute to the state of latency observed in HIV infection. Viruses use many mechanisms to persist in their host, and the molecular interactions evoked by the virus and the cell on each other can influence the outcome of an infection.
D P, Bednarik, T M, Folks
openaire   +2 more sources

Cellular Latency in HIV-1 Infection

Clinics in Laboratory Medicine, 1994
There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1 LTR.
M A, Laughlin, R J, Pomerantz
openaire   +2 more sources

Underlying mechanisms of HIV-1 latency

Virus Genes, 2017
Similarly to other retroviruses, HIV-1 integrates its genome into the cellular chromosome. Expression of viral genes from the integrated viral DNA could then be regulated by the host genome. If the infected cell suppresses viral gene expression, the virus will undergo latency.
Bizhan Romani, Elham Allahbakhshi
openaire   +2 more sources

Molecular mechanisms of HIV-1 proviral latency

Expert Review of Anti-infective Therapy, 2005
While great strides have been made in the treatment of HIV infection with highly active antiretroviral therapy, an actual cure remains out of grasp. One confounding factor is the persistence of a small population of infected cells containing transcriptionally silent but reactivatable HIV proviruses.
Dwayne, Bisgrove, Mary, Lewinski, Frederic, Bushman, Eric, Verdin   +3 more
openaire   +2 more sources

Therapeutics for HIV-1 reactivation from latency

Current Opinion in Virology, 2013
Intensive combined antiretroviral therapy successfully suppresses HIV-1 replication and AIDS disease progression making infection manageable, but it is unable to eradicate the virus that persists in long-lived, drug-insensitive and immune system-insensitive reservoirs thus asking for life-long treatments with problems of compliance, resistance ...
Marco, Sgarbanti, Angela, Battistini
openaire   +2 more sources

Humanized Mouse Models of HIV-1 Latency

Current HIV Research, 2011
The existence of long-lasting cellular reservoirs of HIV-1 is one of the major hurdles in developing effective anti-retroviral therapies. These latently infected cells and tissues efficiently evade immune responses and remain dormant until activated, upon which they can generate a productive HIV-1 infection.
Duyne, Rachel V, Narayanan, Aarthi, K-Hall, Kylene, Saifuddin, Mohammed, Shultz, Leonard D, Kashanchi, Fatah   +5 more
openaire   +2 more sources

The multifactorial nature of HIV-1 latency

Trends in Molecular Medicine, 2004
HIV-1 can avoid host immune responses and antiretroviral drugs through the latent infection of resting memory CD4(+) T cells. Recently, latent viral genomes have been shown to reside within the introns of active host genes. Therefore, latency is not simply due to an inaccessibility of the integrated proviruses to the transcriptional machinery.
Kara, Lassen, Yefei, Han, Yan, Zhou, Janet, Siliciano, Robert F, Siliciano   +4 more
openaire   +2 more sources