Results 161 to 170 of about 66,330 (250)

HIV-1 has a sweet tooth: glucose metabolism drives the multistep process of HIV-1 latency reversal [PDF]

The major barrier to a cure for HIV-1 is the establishment of latency in long-lived CD4+ T cells within lymphoid tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption.
Kayode, Yetunde
core  

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution‐Based Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Cognitive impairment is an inclusive term used to describe the impairment of different domains of cognition. It is a growing public health concern and it can be influenced by hyperthyroidism. While the association between hyperthyroidism and cognitive impairment had been documented in other settings, evidence from Ethiopia ...
Ephrem Tesfaye Mihretie, Girmaye Tesfaye, Yordanos Sintayehu, Ferhan Ahmed, Bereket Gezahegn, Niguse Serbecha, Zerihun Shiferaw, Awel Turki, Fikreab Desta   +8 more
wiley   +1 more source

Preparation, Oral SNEDDS Formulation, and In Vivo Evaluation of the HIV-1 Latency-Reversing Agent EK-16A. [PDF]

Molecules
Jin L, Zhu Y, Yang F, Chen T, Yang X, Tang Y, Cheng Y, Zhang D, Xun J, Liu J, Wang B, Li C, Wang X, Li S, Yu X, Wang Z, Zhang Y, Zhong Q, Ma J, Xue J, Zhu H.   +20 more
europepmc   +1 more source

Knowledge, Attitudes, and Practices Regarding Natural Disaster Management Among Dentists in Southeastern Iran: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Disasters pose a significant concern for healthcare systems. Dentists, as essential members of healthcare teams, possess skills and capabilities valuable for disaster risk management. However, little is known about the knowledge, attitudes, and practices (KAP) of natural disaster risk management among dentists in Iran. This
Fatemeh Jahanimoghadam, Fatemeh Karami Nadik, Amir Mohammad Sabzi, Parya Jangipour Afshar, Hojjat Farahmandnia   +4 more
wiley   +1 more source

Lithium attenuates HIV-1 latency reversal in an autophagy-independent way. [PDF]

iScience
Abdalla AL, Guajardo-Contreras G, Chau BA, Niu M, Murooka T, Mouland AJ.   +5 more
europepmc   +1 more source

The FemTech revolution: Unlocking the potential of new technology for optimizing pregnancy outcomes in low‐ and middle‐income countries and remote areas

International Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 530-553, August 2026.
Abstract Maternal and neonatal mortality and morbidity rates uncover major global health disparities. Despite ongoing efforts, the rates of maternal and neonatal complications remain substantially higher in low‐ and middle‐income countries (LMICs) compared to high‐income countries (HICs). These high rates are the result of several unmet needs in LMICs,
Nir Melamed, Hema Divakar, Mahesh Choolani, Fionnuala M. McAuliffe, Lin Foo, Hassan Shehata, Gabriel Jones, Vyta Senikas, Eline M. Van der Beek, Nandita Palshetkar, Gabriele Saccone, Vincenzo Berghella, Mauricio A. Cuello, Justin Konje, Bhaskar Bhatt, Augusto Cam, Moses Obimbo, Aris Papageorghiou, Moshe Hod, on behalf of the FIGO Committee on Women's Health and Technology   +19 more
wiley   +1 more source

The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation. [PDF]

J Virol
Yang T, Chen M, Zhou M, Deng X, Huang P, Xie S, Zeng J, Luo J, Zhang Y, Ma X, Sun L, Liu J, Zhang H, Li L, Liu B, Qin J, Pan T.   +16 more
europepmc   +1 more source

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. [PDF]

Eur J Med Chem, 2023
Ishii T, Kobayakawa T, Matsuda K, Tsuji K, Ohashi N, Nakahata S, Noborio A, Yoshimura K, Mitsuya H, Maeda K, Tamamura H.   +10 more
europepmc   +1 more source

Strong‐Ties and Weak‐Ties Rationalities: Predicting Public Stigma, Support Networks, and Health Behaviours During the COVID‐19 Pandemic Across Four Societies

International Journal of Psychology, Volume 61, Issue 4, August 2026.
ABSTRACT In this study, we test the theory of strong‐ties and weak‐ties rationalities (STWTR) (Sundararajan 2020) and the criterion validity of its measures using strong‐ties rationality and weak‐ties rationality scales to predict COVID‐19 related perceptions and behaviours.
Rachel Sing‐Kiat Ting, Jane Terpstra‐Tong, May Kyi Zay Hta, Zhong‐Yao Xie, Yi‐Fan Chen, Michael Harris Bond, Kuang‐Hui Yeh, Louise Sundararajan   +7 more
wiley   +1 more source