Results 161 to 170 of about 30,551,261 (265)

Optimizing Tuberculosis Incidence Prediction: A Systematic Review of Hybrid Modeling Approaches and Machine Learning Techniques

Public Health Challenges, Volume 5, Issue 4, December 2026.
This systematic review and meta‐regression compared the performance of statistical, machine learning, and hybrid models in forecasting tuberculosis (TB) incidence. The study followed PRISMA 2020 guidelines and included studies published between 2010 and 2024. Hybrid models, particularly ARIMA‐LSTM, demonstrated superior forecasting accuracy compared to
Dip Bahadur Singh, Bipindra Pandey, Bibek Giri, Yashoda Dangi, Sagun Kharel, Roshan Kumar Mahato   +5 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Protocol for HIV-1 latency reversal using engineered bacteriophage T4 particles. [PDF]

STAR Protoc
Batra H, Rao VB.
europepmc   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source

Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency. [PDF]

PLoS One
Jansen J, Vlaming KE, Helgers LC, Schumacher E, Kaptein TM, Sanders RW, de Bree GJ, Geijtenbeek TBH, Kootstra NA.   +8 more
europepmc   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, Volume 115, Issue 11, Page 2433-2440, November 2026.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Metabolic reprogramming of CD4⁺ T cells by Zaprinast induces HIV-1 latency reversal ex vivo. [PDF]

Retrovirology
De Masson d'Autume V, LeDouce V, Dutilleul A, O'Reilly S, François N, Formiconi E, Angieladis M, Pilosio L, Bendoumou M, Leon AG, Alalwan D, Moore E, McGinty T, Valle-Casuso JC, Macken A, Rohr O, Van Lint C, Sáez-Cirión A, Cotter A, Feeney E, Mallon PWG, Gautier WV.   +21 more
europepmc   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Minimizing Off‐Target Effects of CRISPR‐Cas9 With Optimized sgRNA: Evaluation of Efficiency and Specificity in the Tumor Protein 53 (TP53) Region

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2677-2689, October 2026.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) – Cas9‐based genome editing has emerged as a widely used tool across various disciplines, ranging from molecular biology to gene therapy. This revolutionary technology, which enables precise gene editing, represents a significant advancement in biotechnology, opening new frontiers for ...
Ali Mertcan Köse, Monia Ranalli, Drenka Trivanovic, Irina Maslovaric   +3 more
wiley   +1 more source

Pharmacological METTL3 inhibition attenuates HIV-1 latency reversal in CD4⁺ T cells. [PDF]

Antimicrob Agents Chemother
Mishra T, Edwards A, Wu L.
europepmc   +1 more source