Results 161 to 170 of about 66,203 (260)

Considerations for the clinical use of teplizumab in stage 2 Type 1 diabetes: A Consensus Statement from the British Society of Paediatric Endocrinology and Diabetes (BSPED) and the Association of British Clinical Diabetologists (ABCD)

Diabetic Medicine, Volume 43, Issue 7, July 2026.
Abstract Introduction In 2025, the Medicines and Healthcare products Regulatory Agency (MHRA) approved the use of teplizumab (a monoclonal anti‐CD3 antibody) to delay progression from Stage 2 to Stage 3 Type 1 diabetes in the UK. Methods To address the need for clear guidance on managing patients eligible for teplizumab therapy, the British Society of ...
Renuka P. Dias, M. Loredana Marcovecchio, Ruben H. Willemsen, Fiona Campbell, Ahmad Ashour, Philip Newland‐Jones, Jennifer Cooper, Parth Narendran, Neil P. Wright   +8 more
wiley   +1 more source

“I'm Not Here to Teach You How to Be Gay:” LGBTQ+ Client Experiences of Othering in Emotionally Focused Couple Therapy

Journal of Marital and Family Therapy, Volume 52, Issue 3, July 2026.
ABSTRACT Despite the increasing emphasis on addressing the intersections of client and therapist identity to improve therapeutic outcomes, therapy clients holding marginalized identities continue to experience othering. Othering is a process that engenders marginalization and inequality based on preconceived group identity, involves the hegemonic ...
Caitlin Edwards, Lekie Dwanyen, Andrea Wittenborn, Robert Allan   +3 more
wiley   +1 more source

HIV-1 has a sweet tooth: glucose metabolism drives the multistep process of HIV-1 latency reversal [PDF]

The major barrier to a cure for HIV-1 is the establishment of latency in long-lived CD4+ T cells within lymphoid tissues which readily fuel viral rebound upon antiretroviral therapy (ART) interruption.
Kayode, Yetunde
core  

Global kidney health: Are we failing the silent pandemic?

Journal of Internal Medicine, Volume 300, Issue 1, Page 26-38, July 2026.
Abstract Chronic kidney disease (CKD), although not infectious, has a sharply rising global incidence, alarming rates of death and disability, and the potential to disrupt health systems and economies. Thus, it demands the urgency and global attention of past pandemics.
Taewon Yi, Daniel V. O'Hara, Adeera Levin   +2 more
wiley   +1 more source

Examining bidirectional longitudinal relationships between physical activity and physical function in older breast cancer survivors: The Thinking and Living with Cancer study

Cancer, Volume 132, Issue 12, 15 June 2026.
Abstract Background Older breast cancer survivors are susceptible to cancer‐ and treatment‐related losses in physical function that can negatively affect daily living activities, mobility, and independence. Although physical activity can improve physical function, few studies have focused on older survivors or explored interrelationships between ...
Ashley L. Artese, Xingtao Zhou, Brent J. Small, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Chloe C. Casagrande, Eunji Choi, Harvey J. Cohen, Martine Extermann, Deena Graham, Katherine Hall, Claudine Isaacs, Heather S. L. Jim, Cynthia D. J. Kusters, Brenna C. McDonald, Zev M. Nakamura, Sunita K. Patel, Kelly E. Rentscher, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Wanting Zhai, Judith E. Carroll, Jeanne Mandelblatt   +24 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, Volume 16, Issue 6, Page 1132-1141, June 2026.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Lithium attenuates HIV-1 latency reversal in an autophagy-independent way. [PDF]

iScience
Abdalla AL, Guajardo-Contreras G, Chau BA, Niu M, Murooka T, Mouland AJ.   +5 more
europepmc   +1 more source

CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, Volume 99, Issue 6, Page 1468-1479, June 2026.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation. [PDF]

J Virol
Yang T, Chen M, Zhou M, Deng X, Huang P, Xie S, Zeng J, Luo J, Zhang Y, Ma X, Sun L, Liu J, Zhang H, Li L, Liu B, Qin J, Pan T.   +16 more
europepmc   +1 more source

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. [PDF]

Eur J Med Chem, 2023
Ishii T, Kobayakawa T, Matsuda K, Tsuji K, Ohashi N, Nakahata S, Noborio A, Yoshimura K, Mitsuya H, Maeda K, Tamamura H.   +10 more
europepmc   +1 more source