PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex. [PDF]
Jin J +15 more
europepmc +1 more source
Aspects on latency in HIV-1 infection
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. Unfortunately, ART does not clear the infection or cure the individual from HIV-1.
openaire +1 more source
SARS-CoV-2-Induced Macrophage Polarization Reverses HIV-1 Latency in J-Lat Cells Through TNFα Signaling. [PDF]
Jarmoluk P +6 more
europepmc +1 more source
AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo. [PDF]
Cobos Jiménez V +15 more
europepmc +1 more source
ABSTRACT Introduction Identifying HIV prevention needs is challenging. Common approaches (e.g. public health campaigns, HIV risk scores) have limited sensitivity. Natural language processing techniques, such as topic modelling and computational linguistics, can extract meaning and subjective information from text.
Jessica E. Haberer +10 more
wiley +1 more source
Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models. [PDF]
Batra H +12 more
europepmc +1 more source
ABSTRACT Cytomegalovirus (CMV) is a prevalent herpesvirus that remains typically asymptomatic in immunocompetent individuals but can cause severe, potentially life‐threatening disease in immunocompromised patients. This study assessed the impact of CMV‐associated lower respiratory tract infections (LRTIs), diagnosed by polymerase chain reaction (PCR ...
Theodora Zouvani +10 more
wiley +1 more source
YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation. [PDF]
Zhou C +10 more
europepmc +1 more source
New insights into transcription elongation control of HIV-1 latency and rebound. [PDF]
Mbonye U, Kizito F, Karn J.
europepmc +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source

