Results 171 to 180 of about 66,203 (260)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1552-1566, June 2026.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Nonclinical Considerations for Support of Pregnancy and Lactation in Clinical Trials

Birth Defects Research, Volume 118, Issue 6, June 2026.
ABSTRACT Background Pregnant and breastfeeding individuals remain underrepresented in clinical drug development, leaving health care providers and patients with limited data to inform treatment decisions. Current practice relies heavily on nonclinical developmental and reproductive toxicity (DART) studies in animals, while clinical trials typically ...
Dinesh Stanislaus, Christopher J. Bowman, Kimberly C. Brannen, Sarah N. Campion, Laura M. Carlson, Stephan Chalon, Anthony M. DeLise, Claudia Demarta‐Gatsi, Brian P. Enright, Wendy Halpern, Shermaine Mitchell‐Ryan, Vicki Sutherland, Karen Thacker, Kary Thompson, Belen Tornesi, Steven Van Cruchten, Ronald L. Wange, Tacey White, Connie L. Chen   +18 more
wiley   +1 more source

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex. [PDF]

Nat Commun, 2023
Jin J, Bai H, Yan H, Deng T, Li T, Xiao R, Fan L, Bai X, Ning H, Liu Z, Zhang K, Wu X, Liang K, Ma P, Gao X, Hu D.   +15 more
europepmc   +1 more source

SARS-CoV-2-Induced Macrophage Polarization Reverses HIV-1 Latency in J-Lat Cells Through TNFα Signaling. [PDF]

J Immunol Res
Jarmoluk P, Sviercz FA, Cevallos C, Freiberger RN, López CA, Delpino MV, Quarleri J.   +6 more
europepmc   +1 more source

Rapid Resolution of Grade VI Facial Nerve Paralysis in Ramsay Hunt Syndrome With Prompt Dual Antiviral‐Corticosteroid Therapy: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Ramsay Hunt syndrome, caused by varicella‐zoster virus reactivation, presents with facial paralysis, otalgia, and auricular vesicles. A Tanzanian woman with Grade VI facial palsy was treated with acyclovir and prednisolone, recovering to Grade II within 2 weeks.
Jacob Henry Kitundu, Kasimu Ally Juma, Kajiru Gad Kilonzo, Elichilia Robert Shao, Christine Leons Mmanda   +4 more
wiley   +1 more source

AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo. [PDF]

iScience, 2023
Cobos Jiménez V, Geretz A, Tokarev A, Ehrenberg PK, Deletsu S, Machmach K, Mudvari P, Howard JN, Zelkoski A, Paquin-Proulx D, Del Prete GQ, Subra C, Boritz EA, Bosque A, Thomas R, Bolton DL.   +15 more
europepmc   +1 more source

Fibromyalgia in the Setting of Prior Epstein–Barr Virus Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Accurate diagnosis of fibromyalgia requires careful consideration of overlapping conditions. This case underscores the role of Epstein–Barr virus (EBV) serology in patients with persistent fatigue and pain, while illustrating the challenges of diagnosing fibromyalgia amid concurrent health problems.
Saachi Bhattessa, Tirth Dave, Priti Modi
wiley   +1 more source

Targeted bacteriophage T4 nanoparticles reverse HIV-1 latency in human T cell line models. [PDF]

iScience
Batra H, Zhu J, Jain S, Ananthaswamy N, Mahalingam M, Tao P, Lange C, Hill S, Zhong C, Kearney MF, Hu H, Maldarelli F, Rao VB.   +12 more
europepmc   +1 more source

Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus‐Associated Disorders

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Kaposi sarcoma herpes virus (KSHV) is associated with multiple clinical manifestations, including primary effusion lymphoma, an aggressive CD38+ B cell lymphoma with a plasmablastic phenotype. Case This case describes an antiretroviral therapy‐adherent person with HIV who presented with concurrent KSHV‐related disorders of Kaposi ...
Kandice Roberts, Paula Valiño Ramos, Saurabh Jindal, Vikas Prasad, Yi Shan Lee, Mariam Khanfar, Obi L. Griffith, Malachi Griffith, Jeanne Jiang, Ethel Cesarman, Daniel Rauch, Paul Simonson, Thomas Odeny, Lee Ratner   +13 more
wiley   +1 more source

YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation. [PDF]

PLoS Pathog
Zhou C, He H, Zhang Y, Liu X, Xia M, Qiu J, Wu Z, Rashid HK, Liu W, Peng J, Li L.   +10 more
europepmc   +1 more source