Results 201 to 210 of about 66,330 (250)

Croton oligandrus Pierre & Hutch (Euphorbiaceae) Extracts and Isolated Compounds Reverse HIV-1 Latency. [PDF]

J Exp Pharmacol
Emade Nkwelle C, Babiaka SB, Metuge CS, Liang K, Stephens U, Esemu SN, Zuzga DS, Shuda McGuire K, Montaner LJ, Ndip RN, Tietjen I, Ntie-Kang F.   +11 more
europepmc   +1 more source

GS143, an inhibitor of E3 ligase β-TrCP, reverses HIV-1 latency without activating T cells via unconventional activation of NFκB. [PDF]

PLoS Pathog
Sarkar S, Kobayashi Y, Russnak T, Shen J, Nahass RG, Dougherty JP, Gélinas C.   +6 more
europepmc   +1 more source

Beyond the veil of HIV-1 latency

Viral reservoirs that contain replication competent HIV-1 provirus are the main barrier to an HIV-1 cure. HIV-1 latency is strictly regulated by key host cellular mechanisms at transcriptional and post-transcriptional levels. The aim of the project is to characterize the molecular mechanisms that are involved in the maintenance of HIV-1 latency in in ...
openaire   +1 more source

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal. [PDF]

PLoS Pathog
Cisneros WJ, Soliman SHA, Walter M, Simons LM, Cornish D, De Fabritiis S, Halle AW, Kim EY, Wolinsky SM, Lorenzo-Redondo R, Shilatifard A, Hultquist JF.   +11 more
europepmc   +1 more source

HIV-1 latency reversal and immune enhancing activity of IL-15 is not influenced by sex hormones. [PDF]

JCI Insight
Holmberg CS, Levinger C, Abongwa M, Ceriani C, Archin NM, Siegel M, Ghosh M, Bosque A.   +7 more
europepmc   +1 more source

<i>Ex vivo</i> and <i>in vivo</i> HIV-1 latency reversal by "Mukungulu," a protein kinase C-activating African medicinal plant extract. [PDF]

mBio
Richard K, Yuan Z, Tang H-Y, Goldman AR, Kuthu R, Raphane B, Register ET, Sharma P, Ross BN, Morris J, Williams DE, Cheney C, Wu G, Mounzer K, Laird GM, Zuck P, Andersen RJ, Simonambango S, Andrae-Marobela K, Tietjen I, Montaner LJ.   +20 more
europepmc   +1 more source

ORC1 enhances repressive epigenetic modifications on HIV-1 LTR to promote HIV-1 latency. [PDF]

J Virol
Zhou M, Yang T, Yuan M, Li X, Deng J, Wu S, Zhong Z, Lin Y, Zhang W, Xia B, Wu Y, Wang L, Chen T, Liu R, Pan T, Ma X, Li L, Liu B, Zhang H.   +18 more
europepmc   +1 more source

Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells. [PDF]

Cell Death Discov
Hajikhezri Z, Zygouras I, Sönnerborg A, van Domselaar R.   +3 more
europepmc   +1 more source

Synergistic Activity of Second Mitochondrial-Derived Activator of Caspases Mimetic with Toll-like Receptor 8 Agonist Reverses HIV-1-Latency and Enhances Antiviral Immunity. [PDF]

Int J Mol Sci
Vlaming KE, Jansen J, de Bree GJ, Kootstra NA, Geijtenbeek TBH.   +4 more
europepmc   +1 more source

Genes that influence HIV-1 latency.

Genes described to influence latency included Xpb, Paf1c, and Ccnt1. HDAC inhibitors have described latency reversal potential. We measured total transcription in cells treated with HDAC inhibitors SAHA or Romidepsin to understand molecular mechanisms underlying latency reversal involving HDACi. Cells treated with HDACi experienced an imprinting switch
openaire   +1 more source