Results 201 to 210 of about 66,203 (260)

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, Volume 22, Issue 33, 12 June 2026.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub. [PDF]

Nat Commun
Wang X, Xue Y, Li L, Song J, Jia L, Li X, Fan M, Lu L, Su W, Han J, Lin D, Liu R, Gao X, Guo Y, Xiang Z, Chen C, Wan L, Chong H, He Y, Wang F, Yao K, Zhou Q, Yu D.   +22 more
europepmc   +1 more source

Subgroup Identification via Multiple Change Point Detection: Methods and Applications

WIREs Computational Statistics, Volume 18, Issue 2, June 2026.
Subgroup identification methods facilitate the discovery of clinically meaningful subpopulations with differing disease progression, improving personalized risk assessment and treatment strategies. ABSTRACT Subgroup identification is a significant research area in statistics and machine learning, aiming to partition a heterogeneous population into more
Yaguang Li, Jingli Wang, Da Zhao, Jialiang Li   +3 more
wiley   +1 more source

The Spatial Biology of HIV Transmission and Infection: Imaging the Female and Male Reproductive Tracts

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT HIV transmission through the female and male reproductive tracts is governed by spatially organized interactions between virions, epithelial barriers, and tissue‐resident immune cells. Imaging approaches have been central to defining these earliest events, progressing from classical histology and immunohistochemistry (IHC) to modern ...
Ann M. Carias, Claudia C. Stroupe, Thatiane Russo, Thomas J. Hope   +3 more
wiley   +1 more source

The HIV Reservoir in the Female Reproductive Tract

American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.
ABSTRACT Antiretrovirals can prevent the spread of replicating HIV within the host and decrease the virus in plasma to levels undetectable in clinical assays, and in genital secretions to untransmissible levels. However, during effective treatment with antiretrovirals, infectious HIV persists lifelong because the virus integrates into the host's DNA ...
Sean M. Hughes, Lisa M. Frenkel
wiley   +1 more source

Croton oligandrus Pierre & Hutch (Euphorbiaceae) Extracts and Isolated Compounds Reverse HIV-1 Latency. [PDF]

J Exp Pharmacol
Emade Nkwelle C, Babiaka SB, Metuge CS, Liang K, Stephens U, Esemu SN, Zuzga DS, Shuda McGuire K, Montaner LJ, Ndip RN, Tietjen I, Ntie-Kang F.   +11 more
europepmc   +1 more source

Mental health service users' pre‐ and post‐therapy hospitalization rates: A data linkage study

British Journal of Clinical Psychology, Volume 65, Issue 2, Page 625-638, June 2026.
Abstract Objective To examine the long‐term impact of psychological therapy on physical and mental health hospitalizations. Methods The study design combined case control and data linkage methodologies. Data from 3742 psychological therapies service (PTS) service users and 72,500 matched controls were merged with hospitalizations data in Northern ...
Julie‐Ann Jordan, Adam Elliott, Faye Hill, Kevin F. W. Dyer   +3 more
wiley   +1 more source

Risk Factors for Pneumocystis Jirovecii Pneumonia Among Kidney Transplant Recipients in Southeast France: A 10 Years Case‐Control Study

Clinical Transplantation, Volume 40, Issue 6, June 2026.
ABSTRACT Background Pneumocystis jirovecii is an opportunistic fungus responsible for Pneumocystis pneumonia (PJP) in hosts with impaired cell‐mediated immunity, particularly solid organ transplant recipients. The aim of our study was to identify risk factors associated with PJP in kidney transplant recipients (KTRs).
Solenne Hulot, Raphaël Godefroy, Barbara Doudier, Léa Delorme, Sébastien Cortaredona, Catherine Sartor, Coralie L'Ollivier, Stéphane Burtey, Valérie Moal, Nadim Cassir   +9 more
wiley   +1 more source

GS143, an inhibitor of E3 ligase β-TrCP, reverses HIV-1 latency without activating T cells via unconventional activation of NFκB. [PDF]

PLoS Pathog
Sarkar S, Kobayashi Y, Russnak T, Shen J, Nahass RG, Dougherty JP, Gélinas C.   +6 more
europepmc   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, Volume 27, Issue 6, Page 918-934, June 2026.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source