Results 21 to 30 of about 56,319 (181)

HIV-1: To Splice or Not to Splice, That Is the Question

Viruses, 2021
The transcription of the HIV-1 provirus results in only one type of transcript—full length genomic RNA. To make the mRNA transcripts for the accessory proteins Tat and Rev, the genomic RNA must completely splice.
Ann Emery, Ronald Swanstrom
doaj   +1 more source

HIV-1 Latency by Transition [PDF]

Immunity, 2017
The latent HIV-1 reservoir represents the major barrier for the development of an HIV-1 cure. In this issue of Immunity, Shan et al. (2017) highlight that effector-to-memory transitioning (EMT) CD4+ T cells are particularly permissive for the establishment of latent HIV-1 infection.
Boris, Julg, Dan H, Barouch
openaire   +2 more sources

UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat

mBio, 2021
HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang, Qiao Zhang, Ziyao Wu, Pei Chen, Yifan Huang, Shuwen Liu, Lin Li   +6 more
doaj   +1 more source

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1 [PDF]

, 2014
Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4+ T cells is impervious to cART and represents a major barrier to curing HIV-1 infection. Reactivation of latent HIV-
Chandravanu Dash, DD Richman, Deborah McMahon, DV Havlir, DV Havlir, F Maldarelli, Geneviève Doyon, J Blazkova, John W. Mellors, K Huber, KA Clouse, Kelly Huber, L Colin, L Shan, MC Psallidopoulos, ME Harper, Michele D. Sobolewski, Nicolas Sluis-Cremer, NM Archin, NM Archin, O Kutsch, O Vadas, RJ Morgan Jr, S Palmer, S Reuse, S Xing, SM Schnittman, TM Folks, TM Folks, TW Chun, TW Chun, X Contreras, X Contreras   +32 more
core   +12 more sources

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

mBio, 2021
To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi   +13 more
doaj   +1 more source

HIV-1 latency: From acquaintance to confidant. [PDF]

J Virus Erad
Antiretroviral therapy (ART) has transformed HIV from a fatal disease into manageable circumstance. However, the HIV reservoirs remain a main barrier to complete cure. This review emphasized when, where and how the latency is established, with focus on various host factors and viral proteins.
Yang C, Tong L, Xue J.
europepmc   +3 more sources

Bridging HIV-1 cellular latency and clinical long-term non-progressor: an interactomic view. [PDF]

PLoS ONE, 2013
Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency.
Jin Yang, Zongxing Yang, Hangjun Lv, Yi Lou, Juan Wang, Nanping Wu   +5 more
doaj   +1 more source

Depicting HIV-1 Transcriptional Mechanisms: A Summary of What We Know

Viruses, 2020
Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed.
Antoine Dutilleul, Anthony Rodari, Carine Van Lint   +2 more
doaj   +1 more source

A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency

Viruses, 2023
We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer, Abby Felton, Yennifer Delgado, Harini Srinivasan, Michael Emerman   +4 more
doaj   +1 more source

Epigenetic Heterogeneity in HIV-1 Latency Establishment [PDF]

Scientific Reports, 2015
Despite prolonged antiretroviral therapy, HIV-1 persists as transcriptionally inactive proviruses. The HIV-1 latency remains a principal obstacle in curing AIDS. It is important to understand mechanisms by which HIV-1 latency is established to make the latent reservoir smaller. We present a molecular characterization of distinct populations at an early
Matsuda, Yuka, Kobayashi-Ishihara, Mie, Fujikawa, Dai, Ishida, Takaomi, Watanabe, Toshiki, Yamagishi, Makoto   +5 more
openaire   +2 more sources