Results 31 to 40 of about 56,319 (181)

NSC95397 Is a Novel HIV-1 Latency-Reversing Agent. [PDF]

Viruses, 2023
The latent viral reservoir represents one of the major barriers to curing HIV-1. Focus on the “kick and kill” (also called “shock and kill”) approach, in which virus expression is reactivated, and then cells producing virus are selectively depleted, has led to the discovery of many latency-reversing agents (LRAs) that have furthered our understanding ...
Nichols Doyle R, Yang V, Kayode YI, Damoiseaux R, Taylor HE, Fregoso OI.   +5 more
europepmc   +7 more sources

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]

, 2020
The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle, Deeks, Steven G, Frouard, Julie, Gramatica, Andrea, Greene, Warner C, Hoh, Rebecca, Hsiao, Feng, Jones, R Brad, Lee, Guinevere Q, Lee, Sulggi, Luo, Xiaoyu, Roan, Nadia R, Roychoudhury, Pavitra, Schwarzer, Roland, Telwatte, Sushama, Xie, Guorui, Yukl, Steven A   +16 more
core   +1 more source

HIV-1 transcription and latency: an update [PDF]

Retrovirology, 2013
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia. Reactivation of latently infected cells harboring transcriptionally silent but replication-competent proviruses is a potential source of ...
Van Lint, Carine, Bouchat, Sophie, Marcello, Alexandro   +2 more
openaire   +3 more sources

Hypoxic microenvironment shapes HIV-1 replication and latency [PDF]

Communications Biology, 2020
AbstractViral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary lymphoid tissues exist in a low-oxygen or hypoxic environment in vivo. However, the majority
Zhuang, X, Pedroza-Pacheco, I, Nawroth, I, Kliszczak, AE, Magri, A, Paes, W, Rubio, CO, Yang, H, Ashcroft, M, Mole, D, Balfe, P, Borrow, P, McKeating, JA   +12 more
openaire   +4 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models [PDF]

, 2016
To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed.
Bonczkowski, Pawel, Borch, Alexandra, De Scheerder, Marie-Angélique, De Spiegelaere, Ward, Koenig, Renate, Malatinková, Eva, Melkova, Zora, Vandekerckhove, Linos   +7 more
core   +1 more source

Novel immunological strategies for HIV-1 eradication

Journal of Virus Eradication, 2015
Despite the significant advances in antiretroviral therapy (ART), HIV-1 is able to persist in cellular reservoirs. Preclinical studies suggest that the latent reservoir is established within days of virus exposure, even before virus can be detected in ...
B. Jülg, D.H. Barouch
doaj   +1 more source

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023
A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans, Gerlinde Vansant, Paulien Van de Velde, Zeger Debyser   +3 more
doaj   +1 more source

Splicing factor 3B subunit 1 interacts with HIV Tat and plays a role in viral transcription and reactivation from latency [PDF]

, 2018
The main obstacle to an HIV cure is the transcriptionally inert proviruses that persist in resting CD4 T cells and other reservoirs. None of the current approaches has significantly reduced the size of the viral reservoir.
Kyei, George B, Lagisetti, Chandraiah, Meng, Shanshan, Niu, Austin, Ramani, Rashmi, Ratner, Lee, Webb, Thomas R   +6 more
core   +2 more sources

HIV-1 Latency and Latency Reversal: Does Subtype Matter? [PDF]

Viruses, 2019
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide. In spite of this vast diversity, much of our understanding of latency and latency reversal is largely based
Indra Sarabia, Alberto Bosque
openaire   +2 more sources