Results 21 to 30 of about 54,634 (147)
Viruses, 2022 Allo-HSCT with CCR5Δ32/Δ32 donor cells is the only curative HIV-1 intervention. We investigated the impact of allo-HSCT on the viral reservoir in PBMCs and post-mortem tissue in two patients.
Laura E. P. Huyveneers +22 more
doaj +1 more source
An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes
Scientific Reports, 2021 Human immunodeficiency virus-1 (HIV-1) persistence in the presence of antiretroviral therapy (ART) has halted the development of curative strategies. Measuring HIV persistence is complex due to the low frequency of cells containing virus in vivo. Most of
Callie Levinger +6 more
doaj +1 more source
The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure
Journal of Virus Eradication, 2016 The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova +2 more
doaj +1 more source
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Scientific Reports, 2021 HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are needed ...
Amina Ait-Ammar +12 more
doaj +1 more source
Persistence of VRC01-resistant HIV-1 during antiretroviral therapy [PDF]
Science China Life Sciences, 2013 VRC01, a broadly neutralizing monoclonal antibody (bnmAb), can neutralize a diverse array of HIV-1 isolates by mimicking CD4 binding to the envelope glycoprotein gp120. We have previously demonstrated the presence of VRC01-resistant strains in an HIV-1 infected patient during antiretroviral therapy.
Guo, DongXing +3 more
openaire +2 more sources
Robust CAR-T memory formation and function via hematopoietic stem cell delivery.
PLoS Pathogens, 2021 Due to the durability and persistence of reservoirs of HIV-1-infected cells, combination antiretroviral therapy (ART) is insufficient in eradicating infection.
Anjie Zhen +9 more
doaj +1 more source
Impact of chemotherapy for HIV-1 related lymphoma on residual viremia and cellular HIV-1 DNA in patients on suppressive antiretroviral therapy. [PDF]
PLoS ONE, 2014 The first cure of HIV-1 infection was achieved through complex, multimodal therapy including myeloablative chemotherapy, total body irradiation, anti-thymocyte globulin, and allogeneic stem cell transplantation with a CCR5 delta32 homozygous donor.
Anthony R Cillo +5 more
doaj +1 more source
mBio, 2021 Knowing the mechanisms that govern the persistence of infected CD4+ subpopulations could help us to design new therapies to cure HIV-1 infection. We evaluated the simultaneous distribution of the HIV-1 reservoir in 13 CD4+ subpopulations from 14 HIV-1 ...
Cristina Gálvez +6 more
doaj +1 more source
Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir
Retrovirology, 2018 Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses.
Zheng Wang +3 more
doaj +1 more source
Retrovirology, 2023 A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in the CNS without encephalitis or fail to ...
Rachel M. Podgorski +8 more
doaj +1 more source