Results 31 to 40 of about 54,634 (147)

Human Immune System Mice for the Study of Human Immunodeficiency Virus-Type 1 Infection of the Central Nervous System

Frontiers in Immunology, 2018
Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system (HIS) mice, have emerged as an important and versatile tool for the in vivo study of human immunodeficiency virus-type 1 (HIV-1) pathogenesis ...
Teresa H. Evering, Moriya Tsuji
doaj   +1 more source

The Interplay of HIV and Autophagy in Early Infection

Frontiers in Microbiology, 2021
HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health communities to understand viral infection, to design new drugs or to improve existing ones, as well as to develop advanced therapies and vaccine designs for ...
Romina Cabrera-Rodríguez, Silvia Pérez-Yanes, Judith Estévez-Herrera, Daniel Márquez-Arce, Cecilia Cabrera, Lucile Espert, Julià Blanco, Julià Blanco, Agustín Valenzuela-Fernández   +8 more
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Persistent HIV-1 replication maintains the tissue reservoir during therapy [PDF]

Nature, 2016
Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether
Lorenzo-redondo, Ramon, Fryer, Helen R., Bedford, Trevor, Kim, Eun-young, Archer, John, Kosakovsky Pond, Sergei L., Chung, Yoon-seok, Penugonda, Sudhir, Chipman, Jeffrey G., Fletcher, Courtney V., Schacker, Timothy W., Malim, Michael H., Rambaut, Andrew, Haase, Ashley T., Mclean, Angela R., Wolinsky, Steven M.   +15 more
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Modeling the Mechanisms by Which HIV-Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa. [PDF]

PLoS ONE, 2017
Human immunodeficiency virus (HIV)-infected patients are at an increased risk of co-infection with human papilloma virus (HPV), and subsequent malignancies such as oral cancer. To determine the role of HIV-associated immune suppression on HPV persistence
Meghna Verma, Samantha Erwin, Vida Abedi, Raquel Hontecillas, Stefan Hoops, Andrew Leber, Josep Bassaganya-Riera, Stanca M Ciupe   +7 more
doaj   +1 more source

Assessing proviral competence: current approaches to evaluate HIV-1 persistence

Current Opinion in HIV and AIDS, 2021
Purpose of review Despite decades of suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and fuel viral rebound if therapy is interrupted. The persistence of viral reservoirs in infected individuals is the main obstacle to achieving HIV-1 eradication or a long-term remission.
Aurelija, Cicilionytė, Ben, Berkhout, Alexander O, Pasternak   +2 more
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HIV-1 Proviral Transcription and Latency in the New Era

Viruses, 2020
Three decades of extensive work in the HIV field have revealed key viral and host cell factors controlling proviral transcription. Various models of transcriptional regulation have emerged based on the collective information from in vitro assays and work
Ashutosh Shukla, Nora-Guadalupe P. Ramirez, Iván D’Orso   +2 more
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Differential Persistence of Transmitted HIV-1 Drug Resistance Mutation Classes [PDF]

The Journal of Infectious Diseases, 2011
Transmitted human immunodeficiency virus type 1 (HIV-1) drug resistance (TDR) mutations can become replaced over time by emerging wild-type viral variants with improved fitness. The impact of class-specific mutations on this rate of mutation replacement is uncertain.We studied participants with acute and/or early HIV infection and TDR in 2 cohorts (San
Vivek, Jain, Maria C, Sucupira, Peter, Bacchetti, Wendy, Hartogensis, Ricardo S, Diaz, Esper G, Kallas, Luiz M, Janini, Teri, Liegler, Christopher D, Pilcher, Robert M, Grant, Rodrigo, Cortes, Steven G, Deeks, Frederick M, Hecht   +12 more
openaire   +2 more sources

HIV Expression in Infected T Cell Clones

Viruses
The principal barrier to an HIV-1 cure is the persistence of infected cells harboring replication-competent proviruses despite antiretroviral therapy (ART).
Jason W. Rausch, Shadab Parvez, Sachi Pathak, Adam A. Capoferri, Mary F. Kearney   +4 more
doaj   +1 more source

Persistent HIV-1 transcription during ART: time to reassess its significance?

Current Opinion in HIV and AIDS
Purpose of review Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and reignite viral replication if therapy is interrupted. Persistence of the viral reservoir in people with HIV-1 (PWH) is the main obstacle to an HIV-1 cure. The reservoirs are not transcriptionally silent, and viral transcripts can be
Fombellida-Lopez, Céline, Berkhout, Ben, Darcis, Gilles, Pasternak, Alexander O   +3 more
openaire   +4 more sources

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance

Viruses, 2023
Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated into the human genome remains the main barrier to achieving a cure.
Johannes C. Botha, Matthew Byott, Moira J. Spyer, Paul R. Grant, Kathleen Gärtner, Wilson X. Chen, James Burton, Alasdair Bamford, Laura J. Waters, Carlo Giaquinto, Anna Turkova, Cindy L. Vavro, Eleni Nastouli   +12 more
doaj   +1 more source