Results 41 to 50 of about 54,634 (147)

Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

Journal of Virus Eradication, 2021
The greatest obstacle to an HIV cure is the persistence of latently infected cellular reservoirs in people living with HIV (PLWH) taking antiretroviral therapy (ART).
Xiaorong Peng, Stéphane Isnard, John Lin, Brandon Fombuena, Talat Bessissow, Nicolas Chomont, Jean-Pierre Routy   +6 more
doaj   +1 more source

Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence

Nature Communications
Initiation of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) has been proposed to limit the formation of HIV-1 reservoirs. However, it remains unknown whether temporary ART initiated during PHI has a long-term effect on viral ...
Alexander O. Pasternak, Pien M. van Paassen, Yara L. Verschoor, Jelmer Vroom, Karel A. van Dort, Irma Maurer, Marlous L. Grijsen, Ferdinand W. Wit, Godelieve J. de Bree, Neeltje A. Kootstra, Jan M. Prins, Ben Berkhout   +11 more
doaj   +1 more source

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

Retrovirology, 2010
The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage
Rohr Olivier, Herbein Georges, Le Douce Valentin, Schwartz Christian   +3 more
doaj   +1 more source

Genotypic alteration of HAART-persistent HIV-1 reservoirs in vivo

Virology, 2003
Three HIV-1-infected individuals, on virally-suppressive highly active anti-retroviral therapy (HAART), were treated in vivo with anti-retroviral inhibitor intensification and cell stimulatory therapies in attempting to eradicate latent viral reservoirs. Afterwards, the patients ceased all anti-retroviral drugs.
Kulkosky, Joseph, Sullivan, Julie, Xu, Yan, Malin-Markham, Anne, Otero, Miguel, Calarota, Sandra, Zielinski, Jennifer, Culnan, Derek M, Pomerantz, Roger J   +8 more
openaire   +2 more sources

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4

Frontiers in Immunology, 2023
IntroductionHIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies.
Katie Fisher, Katie Fisher, Timothy E. Schlub, Zoe Boyer, Zoe Boyer, Thomas A. Rasmussen, Thomas A. Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M. Hecht, Steven G. Deeks, Sharon R. Lewin, Sharon R. Lewin, Sharon R. Lewin, Sarah Palmer, Sarah Palmer   +15 more
doaj   +1 more source

HIV-1 replicates and persists in vaginal epithelial dendritic cells

Journal of Clinical Investigation, 2018
HIV-1 acquisition occurs most commonly after sexual contact. To establish infection, HIV-1 must infect cells that support high-level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. Dendritic cells (DCs), present in mucosal epithelia, potentially facilitate HIV-1 acquisition. We show that vaginal epithelial DCs,
Victor Pena-Cruz, Luis M. Agosto, Hisashi Akiyama, Alex Olson, Yvetane Moreau, Jean-Robert Larrieux, Andrew Henderson, Suryaram Gummuluru, Manish Sagar   +8 more
openaire   +2 more sources

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.

PLoS Pathogens, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa   +13 more
doaj   +1 more source

HIV-1 Infection in Persistently HIV-1-Seronegative Individuals: More Reasons for HIV RNA Screening [PDF]

Clinical Infectious Diseases, 2008
Producción Científica The World Health Organization (WHO) has recently released updated guidelines for HIV diagnosis that recommend serum antibody testing by either EIAs or rapid tests and that encourage the identification of unrecognized HIV infections [1]. However, this approach may fail to identify subjects with acute infection.
Ortiz de Lejarazu Leonardo, Raúl, Soriano, Vincent, Eiros Bouza, José María, Arias, Manuel, Toro, Carlos   +4 more
openaire   +1 more source

Sirolimus reduces T cell cycling, immune checkpoint marker expression, and HIV-1 DNA in people with HIV

Cell Reports Medicine
Summary: Key HIV cure strategies involve reversing immune dysfunction and limiting the proliferation of infected T cells. We evaluate the safety of sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, in people with HIV (PWH) and study the impact
Timothy J. Henrich, Ronald J. Bosch, Catherine Godfrey, Hanna Mar, Apsara Nair, Michael Keefer, Carl Fichtenbaum, Daniela Moisi, Brian Clagett, Amanda M. Buck, Amelia N. Deitchman, Francesca Aweeka, Jonathan Z. Li, Daniel R. Kuritzkes, Michael M. Lederman, Priscilla Y. Hsue, Steven G. Deeks, Danielle Campbell, Corey Cutler, Michael Dorosh, Belinda Ha, Elizabeth Hawkins, Christopher Hensel, Nayri Khairalla, Kevin Knowles, Sulggi A. Lee, Susan Pedersen, Justin Ritz, Dylan Ryder, Rafick Sekaly, David L. Shugarts, Becky Straub, Andrew Zolopa   +32 more
doaj   +1 more source

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

EBioMedicine, 2015
Background: Characterising the correlates of HIV persistence improves understanding of disease pathogenesis and guides the design of curative strategies.
Alessandra Ruggiero, Ward De Spiegelaere, Alessandro Cozzi-Lepri, Maja Kiselinova, Georgios Pollakis, Apostolos Beloukas, Linos Vandekerckhove, Matthew Strain, Douglas Richman, Andrew Phillips, Anna Maria Geretti, Paola Vitiello, Nicola Mackie, Jonathan Ainsworth, Anele Waters, Frank Post, Simon Edwards, Julie Fox   +17 more
doaj   +1 more source