Primary HIV-1 resistance: Persistence of transmitted drug resistance mutations [PDF]
Archives of Biological Sciences, 2012 Transmitted drug resistance (TDR) is one of the consequences of the high variability of HIV-1. The widespread use of antiretroviral therapy for the treatment of HIV-1 infection results in a large circulating pool of resistant virus variants.
Nikolić Valentina +7 more
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The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence [PDF]
The Journal of Immunology, 2016 Abstract Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to below the limit of detection of clinical assays. However, even with prolonged suppression of viral replication with ART, viremia rebounds rapidly after treatment interruption. Thus, ART is not curative.
Alexandra J Murray +3 more
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Promoter Methylation of HIV Coreceptor-Related Genes CCR5 and CXCR4: Original Research
VirusesThe persistence of human immunodeficiency virus (HIV) within viral reservoirs poses significant challenges to eradication efforts. Epigenetic alterations, including DNA methylation, are potential factors influencing the latency and persistence of HIV ...
Anna Esman +8 more
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Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency
Frontiers in Cellular and Infection Microbiology, 2023 Alexander O. Pasternak +4 more
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Where in the Cell Are You? Probing HIV-1 Host Interactions through Advanced Imaging Techniques
Viruses, 2016 Viruses must continuously evolve to hijack the host cell machinery in order to successfully replicate and orchestrate key interactions that support their persistence. The type-1 human immunodeficiency virus (HIV-1) is a prime example of viral persistence
Brennan S. Dirk +2 more
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Frontiers in Cellular and Infection Microbiology, 2023 Alexander O. Pasternak +4 more
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HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
Journal of Virus Eradication, 2015 Advances in the treatment of HIV infection have dramatically reduced the death rate from AIDS and improved the quality of life of many HIV-infected individuals. However, the possible long-term toxicity associated with antiretroviral therapy (ART), stigma
Deanna A. Kulpa, Nicolas Chomont
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Human macrophages support persistent transcription from unintegrated HIV-1 DNA
Virology, 2008 Retroviruses require integration of their RNA genomes for both stability and productive viral replication. In HIV infection of non-dividing, resting CD4 T cells, where integration is greatly impeded, the reverse transcribed HIV DNA has limited biological activity and a short half-life. In metabolically active and proliferating T cells, unintegrated DNA
Kelly, Jeremy +5 more
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The establishment of rodent cell lines persistently producing HIV-1
Virology, 1992 Animal cells differ in susceptibility to HIV-1 infection. To identify rodent cells which are permissive to HIV-1 replication, we transfected murine and rat cells with an infectious clone of HIV-1 and a vector containing the chloramphenicol acetyl transferase gene under the control of HIV-1 LTR.
Y, Mizrachi, L, Sternas, D J, Volsky
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Sex differences in HIV-1 persistence and the implications for a cure. [PDF]
Front Glob Womens Health, 2022 Rao S.
europepmc +1 more source