Results 61 to 70 of about 54,634 (147)

Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial. [PDF]

Nat Med, 2023
Gunst JD, Højen JF, Pahus MH, Rosás-Umbert M, Stiksrud B, McMahon JH, Denton PW, Nielsen H, Johansen IS, Benfield T, Leth S, Gerstoft J, Østergaard L, Schleimann MH, Olesen R, Støvring H, Vibholm L, Weis N, Dyrhol-Riise AM, Pedersen KBH, Lau JSY, Copertino DC, Linden N, Huynh TT, Ramos V, Jones RB, Lewin SR, Tolstrup M, Rasmussen TA, Nussenzweig MC, Caskey M, Reikvam DH, Søgaard OS.   +32 more
europepmc   +1 more source

Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence. [PDF]

Immunity, 2023
Wei Y, Davenport TC, Collora JA, Ma HK, Pinto-Santini D, Lama J, Alfaro R, Duerr A, Ho YC.   +8 more
europepmc   +1 more source

Fighting HIV-1 Persistence: At the Crossroads of "Shoc-K and B-Lock". [PDF]

Pathogens, 2021
Acchioni C, Palermo E, Sandini S, Acchioni M, Hiscott J, Sgarbanti M.   +5 more
europepmc   +1 more source

Intact proviruses are enriched in the colon and associated with PD-1+TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapyResearch in context

EBioMedicine
Summary: Background: The persistence of intact replication-competent HIV-1 proviruses is responsible for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to the high number of infected target cells.
Camille Vellas, Manon Nayrac, Nived Collercandy, Mary Requena, Nicolas Jeanne, Justine Latour, Chloé Dimeglio, Michelle Cazabat, Karl Barange, Laurent Alric, Nicolas Carrere, Guillaume Martin-Blondel, Jacques Izopet, Pierre Delobel   +13 more
doaj   +1 more source

Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses. [PDF]

Trends Immunol, 2022
Linden N, Jones RB.
europepmc   +1 more source

Associations Between Multiple Measures of HIV-1 Persistence in Persons on Suppressive Antiretroviral Therapy. [PDF]

J Infect Dis, 2022
Bosch RJ, Gandhi RT, Mar H, Eron JJ, Cyktor JC, McMahon DK, Mellors JW.   +6 more
europepmc   +1 more source

A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro. [PDF]

Cell Rep Methods, 2021
Eshetu A, Ho YC.
europepmc   +1 more source

Pharmacologic control of homeostatic and antigen-driven proliferation to target HIV-1 persistence. [PDF]

Biochem Pharmacol, 2021
Innis EA, Levinger C, Szaniawski MA, Williams ESCP, Alcamí J, Bosque A, Schiffer JT, Coiras M, Spivak AM, Planelles V.   +9 more
europepmc   +1 more source

BACH2-driven tissue resident memory programs promote HIV-1 persistence

SUMMARYTranscription repressor BACH2 redirects short-lived terminally differentiated effector into long-lived memory cells. We postulate that BACH2-mediated long-lived memory programs promote HIV-1 persistence in gut CD4+ T cells. We coupled single-cell DOGMA-seq and TREK-seq to capture chromatin accessibility, transcriptome, surface proteins, T cell ...
Wei, Yulong, Ma, Haocong Katherine, Wong, Michelle E., Papasavvas, Emmanouil, Konnikova, Liza, Tebas, Pablo, Morgenstern, Ricardo, Montaner, Luis J., Ho, Ya-Chi   +8 more
openaire   +2 more sources

Exploring potential associations between the human microbiota and reservoir of latent HIV

Retrovirology
Background The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-infected cells ...
Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone   +2 more
doaj   +1 more source