Results 81 to 90 of about 33,958 (207)

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

CD161⁺ CD4⁺ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals

mBio, 2019
The presence of an extremely stable latent reservoir of HIV-1 is the major obstacle to eradication, despite effective antiretroviral therapy (ART). Recent studies have shown that clonal expansion of latently infected cells without viral reactivation is ...
Xiaomin Li, Zhaoli Liu, Qijuan Li, Ronglin Hu, Lu Zhao, Yanyan Yang, Jiacong Zhao, Zhuoqiong Huang, Hongbo Gao, Linghua Li, Weiping Cai, Kai Deng   +11 more
doaj   +1 more source

Sexually Transmitted Infection Prevalence and Determinants Among Sexual Health Clinic Attendees in Bucharest, Romania

International Journal of Dermatology, EarlyView.
Cross‐sectional study among 70 sexual health clinic attendees (70% MSM) in Bucharest combining multisite STI testing with knowledge, attitudes, and practices assessment. Key findings include 35.5% bacterial STI prevalence, essential extragenital testing, and cost barriers to screening uptake.
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Exploring potential associations between the human microbiota and reservoir of latent HIV

Retrovirology
Background The rapid establishment and persistence of latent HIV-1 reservoirs is one of the main obstacles towards an HIV cure. While antiretroviral therapy supresses viral replication, it does not eradicate the latent reservoir of HIV-1-infected cells ...
Nel Marín-Sánchez, Roger Paredes, Alessandra Borgognone   +2 more
doaj   +1 more source

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

Journal of Virus Eradication, 2016
The mechanisms for the establishment and the persistence of the latent HIV-1 reservoir remain to be completely defined. HIV-1 infection is characterised by the integration of the reverse transcribed proviral DNA into the host's genome.
Maja Kiselinova, Ward De Spiegelaere, Linos Vandekerckhove   +2 more
doaj   +1 more source

Seroprevalence and Risk Factors for Hepatitis E Virus in a Metropolis of Northeastern Brazil: A Population‐Based Survey

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. While traditionally linked to poor sanitation in endemic areas, evidence shows increasing circulation in developed settings. In Brazil, however, population‐based data remain limited.
Carolline A. Mariz, Cynthia Braga, Wayner V. Souza, Carlos F. Luna, André Luiz Sá de Oliveira, Elisa de Almeida Neves de Azevedo, Clarice N. L. de Morais, Maria de Fatima P. M. Albuquerque, Edmundo Pessoa Lopes   +8 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

The role of T cells in sepsis of distinct infectious aetiologies

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Pathogen‐specific sepsis induces mitochondrial dysfunction in T cells, leading to functional alterations. Single‐cell transcriptomics reveals subtype‐specific impairments involving reactive oxygen species accumulation, mtDNA damage, calcium dysregulation, and metabolic reprogramming.
Xuanqi Liu, Bijun Zhu, Wanxin Duan, Ruixiang Kang, Xiangdong Wang, Liyang Li   +5 more
wiley   +1 more source

Factors associated with unquantifiable total HIV-1 DNA in peripheral blood in persons living with HIV: An observational study

Journal of Virus Eradication
Background: The human immunodeficiency virus type 1 (HIV-1) cannot be eradicated even with suppressive antiretroviral therapy because its retrotranscribed genome integrates into the DNA of host cells, creating a long-term reservoir.
Aurélie Ram, Vanessa Rascon Velasco, Gilbert Mchantaf, Véronique Avettand-Fénoël, Jean-Paul Viard   +4 more
doaj   +1 more source