Results 1 to 10 of about 28,737 (162)
β-catenin regulates HIV latency and modulates HIV reactivation. [PDF]
PLoS Pathogens, 2022 Latency is the main obstacle towards an HIV cure, with cure strategies aiming to either elicit or prevent viral reactivation. While these strategies have shown promise, they have only succeeded in modulating latency in a fraction of the latent HIV ...
Hannah J Barbian +6 more
doaj +5 more sources
The role of Tat in HIV latency and reactivation [PDF]
Frontiers in ImmunologyHIV persists during therapy due the existence of a latently infected reservoir in which viral gene expression is silenced. This reservoir thus represents the primary barrier to a cure for HIV.
David M. Margolis, Edward P. Browne
doaj +2 more sources
The multifaceted nature of HIV latency. [PDF]
J Clin Invest, 2021 Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during ART. A large number of studies conducted during the past 20 years have shown that HIV persists in a small pool of cells harboring integrated and replication ...
Dufour C +3 more
europepmc +6 more sources
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation [PDF]
Frontiers in Immunology, 2022 The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute ...
Ifeanyi Jude Ezeonwumelu +22 more
doaj +2 more sources
Innate immune regulation in HIV latency models. [PDF]
Retrovirology, 2022 AbstractBackgroundInnate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the HIV reservoir in vivo.
Olson RM +8 more
europepmc +4 more sources
Frontiers in Immunology, 2022 The main obstacle to cure HIV-1 is the latent reservoir. Antiretroviral therapy effectively controls viral replication, however, it does not eradicate the latent reservoir. Latent CD4+ T cells are extremely rare in HIV-1 infected patients, making primary
Anne Inderbitzin +9 more
doaj +1 more source
mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) cannot be completely eliminated because of existence of the latent HIV-1 reservoir. However, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete.
Xinyi Yang +25 more
doaj +1 more source
Cold Spring Harbor Perspectives in Medicine, 2011 HIV-1 can establish a state of latent infection at the level of individual T cells. Latently infected cells are rare in vivo and appear to arise when activated CD4(+) T cells, the major targets cells for HIV-1, become infected and survive long enough to revert back to a resting memory state, which is nonpermissive for viral gene expression.
Robert F, Siliciano, Warner C, Greene
openaire +2 more sources
Viruses, 2023 We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency ...
Terry L. Hafer +4 more
doaj +1 more source
Bioinformatics and HIV Latency [PDF]
Current HIV/AIDS Reports, 2015 Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan.
Ciuffi, Angela +4 more
openaire +6 more sources